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JNCI:对有吸烟史人群应谨慎推荐低剂量CT筛查

2015-10-26 徐媛 MedSci原创

基于目前美国预防服务工作组(USPSTF)推荐,应该对具有每年吸烟数量在30包以上的人群、曾经吸烟、近15年内戒烟的人群进行低剂量计算机断层扫描肺癌筛查。本研究调查了每年吸烟数量在20-29包的吸烟人群及有吸烟史人群肺癌发生风险,以及这些人群是否有不同的人口统计特征。 研究人员通过查看胸部X射线进行前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验数据进行了的一项随机分配试验,受试者在55岁到74岁。受试

基于目前美国预防服务工作组(USPSTF)推荐,应该对具有每年吸烟数量在30包以上的人群、曾经吸烟、近15年内戒烟的人群进行低剂量计算机断层扫描肺癌筛查。本研究调查了每年吸烟数量在20-29包的吸烟人群及有吸烟史人群肺癌发生风险,以及这些人群是否有不同的人口统计特征。

研究人员通过查看胸部X射线进行前列腺癌、肺癌、结直肠癌卵巢癌筛查试验数据进行了的一项随机分配试验,受试者在55岁到74岁。受试人群完成了关于吸烟史的基线调查问卷。校正受试者的性别年龄,利用Cox比例风险模型评估受试者患肺癌的风险。统计测试都是双面的。

在这项PLCO研究中,研究人员收纳了18114名有吸烟史的烟民,目前低剂量CT筛查烟民12243名和目前每年吸烟数量在20-29包的烟民。与曾经每年吸烟数量在30包以上的烟民来说,每年吸烟数量在20-29包的烟民的风险比为1.07 (95% [CI] = 0.75 to 1.5)。基于NHIS数据,在美国有1000万人群接受低剂量CT筛查,而现在又160万人群是具有20-29包年吸烟史的目前吸烟者(16%, 95% CI = 13.6% to 19.0%)。有20-29包年吸烟史的目前吸烟者与符合目前USPSTF指南的人群相比,女性发病率要高于男性(22.2%, 95% CI = 17.9% to 26.7%; vs 12.2%, 95% CI = 9.3% to 15.3%, P <0 .001)而且少数民族居多(30.0%, 95% CI = 24.2% to 36.0%; vs 14.1%, 95% CI = 11.1% to 17.0%, P < 0.001)。

以上研究结果表明,应该对20-29包年烟史的当前吸烟者谨慎推荐低剂量CT筛查。

原始出处

Pinsky PF1, Kramer BS2.Lung Cancer Risk and Demographic Characteristics of Current 20-29 Pack-year Smokers: Implications for Screening.J Natl Cancer Inst. 2015 Oct 19

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    2015-10-28 heli0118
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    2015-10-27 三三五五

    不理解为什么

    0

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    2015-10-26 lixh1719

    吸烟还和CT有关!

    0

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