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Int J Oral Max Surg:氯硝西泮和阿米替林治疗灼口综合征的止痛效果

2017-10-24 MedSci MedSci原创

这项回顾性研究旨在评估氯硝西泮和阿米替林治疗灼口综合征(BMS)的疗效。

这项回顾性研究旨在评估氯硝西泮和阿米替林治疗灼口综合征(BMS)的疗效。

诊断为BMS的患者中进行单中心回顾性队列研究。患者服用氯硝西泮或阿米替林,并在治疗前,治疗后6周和3个月用10点口头数字量表(VNS)评估其疼痛。使用Kruskal-Wallis检验评估平均疼痛缓解值。

实验纳入39名患者(85%女性),平均年龄为65±10.5岁。治疗前,氯硝西泮治疗组患者平均VNS评分为7.1±2.0,阿米替林治疗组平均VNS评分为7.5±1.1。治疗6周后氯硝西汀和阿米替林组平均VNS评分分别为4.9±2.4和6.1±2.6,(P = 0.498),治疗3个月后氯硝西汀和阿米替林组平均VNS评分分别为 4.4 ± 2.0 和 4.1 ± 2.7,(P = 0.509)。所以两种治疗方法在疼痛减轻方面无差异。

实验表明氯硝西泮以及阿米替林可能是BMS的有效治疗方法。

原始出处:

M. Fenelon, et al. Pain-relieving effects of clonazepam and amitriptyline in burning mouth syndrome: a retrospective study. International Journal of Oral and Maxillofacial Surgery. 2017 November. doi: 10.1016/j.ijom.2017.03.032

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    2018-06-10 小几洁
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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Tue Oct 24 00:17:45 CST 2017, time=2017-10-24, status=1, ipAttribution=)]
    2017-10-24 飛歌

    厉害了我的哥

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2020272, encodeId=dfcf20202e224, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Sun Jun 10 03:02:00 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076821, encodeId=482b20e682193, content=<a href='/topic/show?id=2e966695542' target=_blank style='color:#2F92EE;'>#灼口综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66955, encryptionId=2e966695542, topicName=灼口综合征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Wed Aug 22 08:02:00 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1994560, encodeId=8c5d1994560fd, content=<a href='/topic/show?id=6bdc641099a' target=_blank style='color:#2F92EE;'>#氯硝西泮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64109, encryptionId=6bdc641099a, topicName=氯硝西泮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sun Sep 30 06:02:00 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405540, encodeId=47c714055400c, content=<a href='/topic/show?id=597b631634d' target=_blank style='color:#2F92EE;'>#止痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63163, encryptionId=597b631634d, topicName=止痛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8da42553722, createdName=zhangxingru, createdTime=Wed Oct 25 15:02:00 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430989, encodeId=67ce14309891c, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Oct 25 15:02:00 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457319, encodeId=daea145e319b1, content=<a href='/topic/show?id=570e9e9186d' target=_blank style='color:#2F92EE;'>#阿米替林#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97918, encryptionId=570e9e9186d, topicName=阿米替林)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb845885644, createdName=zhyy90, createdTime=Wed Oct 25 15:02:00 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255487, encodeId=1a0c25548e0b, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Oct 24 05:59:58 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255482, encodeId=6751255482cf, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Oct 24 05:47:20 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255468, encodeId=965f255468b6, content=谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Tue Oct 24 00:17:45 CST 2017, time=2017-10-24, status=1, ipAttribution=)]
    2017-10-24 yjs木玉

    好好好好好好好好

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2020272, encodeId=dfcf20202e224, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Sun Jun 10 03:02:00 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076821, encodeId=482b20e682193, content=<a href='/topic/show?id=2e966695542' target=_blank style='color:#2F92EE;'>#灼口综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66955, encryptionId=2e966695542, topicName=灼口综合征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Wed Aug 22 08:02:00 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1994560, encodeId=8c5d1994560fd, content=<a href='/topic/show?id=6bdc641099a' target=_blank style='color:#2F92EE;'>#氯硝西泮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64109, encryptionId=6bdc641099a, topicName=氯硝西泮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sun Sep 30 06:02:00 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405540, encodeId=47c714055400c, content=<a href='/topic/show?id=597b631634d' target=_blank style='color:#2F92EE;'>#止痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63163, encryptionId=597b631634d, topicName=止痛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8da42553722, createdName=zhangxingru, createdTime=Wed Oct 25 15:02:00 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430989, encodeId=67ce14309891c, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Oct 25 15:02:00 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457319, encodeId=daea145e319b1, content=<a href='/topic/show?id=570e9e9186d' target=_blank style='color:#2F92EE;'>#阿米替林#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97918, encryptionId=570e9e9186d, topicName=阿米替林)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb845885644, createdName=zhyy90, createdTime=Wed Oct 25 15:02:00 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255487, encodeId=1a0c25548e0b, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Oct 24 05:59:58 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255482, encodeId=6751255482cf, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Oct 24 05:47:20 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255468, encodeId=965f255468b6, content=谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Tue Oct 24 00:17:45 CST 2017, time=2017-10-24, status=1, ipAttribution=)]
    2017-10-24 Drhzm308

    谢谢.学习了

    0

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