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CCLM:一项用于同时测量血清中氟康唑,伏立康唑,泊沙康唑,伊曲康唑和羟基特他康唑浓度的快速UPLC-MS / MS测定方法

2017-06-29 MedSci MedSci原创

近日,国际杂志《Clinical Chemistry and Laboratory Medicine》在线发表了一项关于采用快速简单的超高效液相色谱 - 串联质谱(UPLC-MS / MS)方法对人血清中的氟康唑,伏立康唑,泊沙康唑,伊曲康唑和羟基特他康唑进行测定的研究。

近日,国际杂志《Clinical Chemistry and Laboratory Medicine》在线发表了一项关于采用快速简单的超高效液相色谱 - 串联质谱(UPLC-MS / MS)方法对人血清中的氟康唑,伏立康唑,泊沙康唑,伊曲康唑和羟基特他康唑进行测定的研究。

三唑类抗真菌剂对于治疗和预防真菌感染至关重要。 显著的药物动力学变化加上临床需要更快的周转时间增加了对这些药物进行内部治疗监测的需求,而这种监测最好在质谱的平台进行。然而,由于技术和后勤的保障方面的原因限制了这些平台在医院实验室的广泛的利用。在这里,研究人员介绍了一种适合纳入医院临床实验室快速简单的超高效液相色谱 - 串联质谱(UPLC-MS / MS)方法的开发及验证,用于测量人血清中的氟康唑,伏立康唑,泊沙康唑,伊曲康唑和羟基特他康唑。

在氘代内标物存在下使用蛋白质沉淀制备血清样品(20μL)。使用反相UPLC进行色谱分离,并使用正电喷雾电离和碰撞诱导的解离MS进行分析。

研究表明,总分析运行时间在3分钟内。所有分析物显示线性(r2> 0.998范围为0.110μg/ mL(氟康唑的1-100μg/ mL),准确度和精确度在可接受范围内(所有测试水平下DEV <15%,CV <15%),在适当的储存条件下的稳定性良好,并与参考实验室结果有良好的相关。

为了满足医院实验室的需要,研究人员所开发的这种用于监测多种三唑抗真菌剂的简单快速的UPLC-MS / MS方法可以用于患者药的临床使用和管理

原始出处:

Sankha S. Basu, Athena Petrides, Donald S. Mason.et.al. A rapid UPLC-MS/MS assay for the simultaneous measurement of fluconazole, voriconazole, posaconazole, itraconazole, and hydroxyitraconazole concentrations in serum.

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    2017-06-29 139****5926

    好文章学习了

    0

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    2017-06-29 执着追梦

    学习,先谢谢分享

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1650126, encodeId=7f9316501265a, content=<a href='/topic/show?id=7462256860e' target=_blank style='color:#2F92EE;'>#伏立康唑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25686, encryptionId=7462256860e, topicName=伏立康唑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3a823964486, createdName=lancelotzzl, createdTime=Sun Dec 24 05:37:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1662233, encodeId=c74a16622336b, content=<a href='/topic/show?id=6a426545472' target=_blank style='color:#2F92EE;'>#测定#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65454, encryptionId=6a426545472, topicName=测定)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Feb 10 23:37:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544452, encodeId=d0c915444526b, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Fri Jun 30 23:37:00 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603294, encodeId=40181603294fb, content=<a href='/topic/show?id=ba9a6392545' target=_blank style='color:#2F92EE;'>#氟康唑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63925, encryptionId=ba9a6392545, topicName=氟康唑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d68c19021189, createdName=yhj-time, createdTime=Fri Jun 30 23:37:00 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216644, encodeId=8f082166443f, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Thu Jun 29 12:02:08 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216640, encodeId=a8bf2166407e, content=学习,先谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Thu Jun 29 11:33:45 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216615, encodeId=55a4216615b8, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Jun 29 09:34:29 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216603, encodeId=45c521660303, content=学习了不少事情, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Thu Jun 29 08:45:59 CST 2017, time=2017-06-29, status=1, ipAttribution=)]
    2017-06-29 明月清辉

    谢谢分享,学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1650126, encodeId=7f9316501265a, content=<a href='/topic/show?id=7462256860e' target=_blank style='color:#2F92EE;'>#伏立康唑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25686, encryptionId=7462256860e, topicName=伏立康唑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3a823964486, createdName=lancelotzzl, createdTime=Sun Dec 24 05:37:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1662233, encodeId=c74a16622336b, content=<a href='/topic/show?id=6a426545472' target=_blank style='color:#2F92EE;'>#测定#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65454, encryptionId=6a426545472, topicName=测定)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Feb 10 23:37:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544452, encodeId=d0c915444526b, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Fri Jun 30 23:37:00 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603294, encodeId=40181603294fb, content=<a href='/topic/show?id=ba9a6392545' target=_blank style='color:#2F92EE;'>#氟康唑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63925, encryptionId=ba9a6392545, topicName=氟康唑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d68c19021189, createdName=yhj-time, createdTime=Fri Jun 30 23:37:00 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216644, encodeId=8f082166443f, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Thu Jun 29 12:02:08 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216640, encodeId=a8bf2166407e, content=学习,先谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Thu Jun 29 11:33:45 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216615, encodeId=55a4216615b8, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Jun 29 09:34:29 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216603, encodeId=45c521660303, content=学习了不少事情, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Thu Jun 29 08:45:59 CST 2017, time=2017-06-29, status=1, ipAttribution=)]
    2017-06-29 圣艮山

    学习了不少事情

    0

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