Cell Death Dis：中国科学家发现抑制鼻咽癌生长转移新机制

2015-01-30 佚名生物谷

近日，国际生物学期刊cell death ＆disease在线发表了来自中山大学一研究小组的最新研究成果。他们通过基因芯片分析发现miR-34c在鼻咽癌（NPC）中发生下调，并通过实验证明miR-34c能够通过直接抑制原癌基因MET表达抑制鼻咽癌肿瘤生长和转移。这项研究对治疗鼻咽癌提供了机制上的借鉴意义。研究人员通过对NPC细胞系和病人组织样本进行分析发现，miR-34c在细胞和组织内均发生明

近日，国际生物学期刊cell death ＆disease在线发表了来自中山大学一研究小组的最新研究成果。他们通过基因芯片分析发现miR-34c在鼻咽癌（NPC）中发生下调，并通过实验证明miR-34c能够通过直接抑制原癌基因MET表达抑制鼻咽癌肿瘤生长和转移。这项研究对治疗鼻咽癌提供了机制上的借鉴意义。

研究人员通过对NPC细胞系和病人组织样本进行分析发现，miR-34c在细胞和组织内均发生明显表达下调。通过在细胞系内过量表达miR-34c发现，NPC细胞存活能力，集落形成，细胞迁移及侵袭能力都受到明显抑制，同时体内实验也证明miR-34c过表达能够抑制肿瘤生长及肺转移。研究人员通过实验发现miR-34c能够直接作用于原癌基因MET，miR-34c过表达能够明显降低MET的mRNA和蛋白水平。在细胞内敲低MET能够抑制NPC细胞增殖，迁移和侵袭，同时恢复MET表达能够改变miR-34c对肿瘤细胞的抑制效应。除此之外，研究人员还发现了一种能够恢复miR-34c表达的化学分子。

综上所述，该项研究发现miR-34c能够通过影响MET表达抑制鼻咽癌肿瘤生长和转移,关于miR-34c/MET新通路的发现或许可以为进一步研究NPC发展机制以及开发治疗NPC的药物提供重要借鉴意义。

原始出处

Li YQ1, Ren XY1, He QM1, Xu YF1, Tang XR1, Sun Y1, Zeng MS1, Kang TB1, Liu N1, Ma J1.MiR-34c suppresses tumor growth and metastasis in nasopharyngeal carcinoma by targeting MET.Cell Death Dis. 2015 Jan 22

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2015-12-28 zhaozhouchifen

#Cell#

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2015-05-12 guihongzh

#中国科学#

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2015-07-13 旅苦化文_208

#科学家发现#

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2015-08-29 维他命

#CEL#

61 0
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2015-04-04 cmj8wellington

#Dis#

69 0
[GetPortalCommentsPageByObjectIdResponse(id=1869010, encodeId=7fbf1869010ba, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon Dec 28 19:39:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024207, encodeId=e2a0202420e4d, content=<a href='/topic/show?id=79f4219392b' target=_blank style='color:#2F92EE;'>#中国科学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21939, encryptionId=79f4219392b, topicName=中国科学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Tue May 12 13:39:00 CST 2015, time=2015-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1802242, encodeId=a54718022429b, content=<a href='/topic/show?id=acfae485578' target=_blank style='color:#2F92EE;'>#科学家发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74855, encryptionId=acfae485578, topicName=科学家发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Mon Jul 13 14:39:00 CST 2015, time=2015-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959261, encodeId=ea44195926126, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Aug 29 06:39:00 CST 2015, time=2015-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011949, encodeId=d1b220119496a, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Apr 04 20:39:00 CST 2015, time=2015-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516874, encodeId=e91f15168e462, content=<a href='/topic/show?id=f1232194031' target=_blank style='color:#2F92EE;'>#中国科学家#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21940, encryptionId=f1232194031, topicName=中国科学家)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbca11021083, createdName=12498e5fm15(暂无昵称), createdTime=Sun Feb 01 02:39:00 CST 2015, time=2015-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531386, encodeId=559b15313866e, content=<a href='/topic/show?id=770e5e9457' target=_blank style='color:#2F92EE;'>#Death#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5794, encryptionId=770e5e9457, topicName=Death)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32e312278742, createdName=cy0328, createdTime=Sun Feb 01 02:39:00 CST 2015, time=2015-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14886, encodeId=ea07148864f, content=意义不大, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Fri Jan 30 19:55:00 CST 2015, time=2015-01-30, status=1, ipAttribution=)]
2015-02-01 12498e5fm15(暂无昵称)

#中国科学家#

58 0
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2015-02-01 cy0328

#Death#

52 0
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2015-01-30 lovetcm

意义不大

163 0

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