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Ann Rheum Dis:强直性脊柱炎的静脉血栓栓塞风险

2019-02-16 xiangting MedSci原创

这些研究结果表明,一般AS人群的VTE风险升高。这种风险在诊断后的第一年最为突出。

包括肺栓塞(PE)和深静脉血栓形成(DVT)的静脉血栓栓塞(VTE)可能危及生命。有研究发现炎性疾病中VTE的发病率升高。迄今为止,评估强直性脊柱炎(AS)患者VTE风险是否也升高的证据很少。

研究人员利用包括省内所有居民的加拿大不列颠哥伦比亚省医疗保健数据库,对偶发性AS病例中的偶发性PE、DVT和总VTE进行了匹配队列分析,并将其与无AS一般人群中随机选择的个体进行比较。计算了VTE的发病率(IRs),调整传统风险因素后使用Cox模型进行多因素分析。

7190例AS患者中,35例发生PE,47例发生DVT。AS患者每1000人年的PE、DVT和总VTE的IRs为0.79、1.06、1.56,而对照队列为0.40、0.50、0.77。PE、DVT和VTE的相应完全调整HRs(95%CI)分别为1.36(0.92至1.99)、1.62(1.16至2.26)和1.53(1.16至2.01)。诊断第一年的PE、DVT和VTE风险最高,HR(95%CI)分别为2.88(0.87至9.62)、2.20(0.80至6.03)和2.10(0.88至4.99)。

这些研究结果表明,一般AS人群的VTE风险升高。这种风险在诊断后的第一年最为突出。

始出处:
Juan Antonio Avina-Zubieta. Risk of venous thromboembolism in ankylosing spondylitis: a general population-based study. Ann Rheum Dis. 08 February 2019.

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    2019-07-10 fusion
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    2019-12-28 zywlvao
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    2019-06-12 xue8602
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    2019-02-16 1ddf0692m34(暂无匿称)

    学习了,长知识

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