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CCLM:检测炎症性肠病患者血清中CUZD1自身抗体的新型免疫测定法

2017-09-10 MedSci MedSci原创

近日,国际杂志《Clinical Chemistry and Laboratory Medicine》在线发表了一篇关于检测炎症性肠病患者血清中CUZD1自身抗体的新型免疫测定法的研究。

近日,国际杂志《Clinical Chemistry and Laboratory Medicine》在线发表了一篇关于检测炎症性肠病患者血清中CUZD1自身抗体的新型免疫测定法的研究。 研究发现在具有炎症性肠病(IBD)的患者中可检测到胰腺自身抗体(PAB)。PAB在克罗恩病(CrD)中的流行率高于在溃疡性结肠炎(UC)。糖蛋白2(GP2)和最近的CUB及透明带状结构域蛋白1(CUZD1)已经被鉴定为PAB的自身抗原。最近,有研究通过间接免疫荧光(IIF)测定来评估CUZD1自身抗体的临床应用。在本研究中,研究人员开发并验证了用于检测CUZD1自身抗体的新型免疫测定法。 研究人员将重组CUZD1蛋白作为固相抗原用于开发检测IgG和IgA CUZD1自身抗体的两种免疫检测。对来自分析100例CrD患者100例UC患者,129例患者和50例对照者的血清样本评估各种自身免疫性疾病(vADs)。 用于检测IgG和IgA CUZD1特异性抗体的两种免疫荧光测定,在12.5%(25/200)IBD患者中检测到了CUZD1自身抗体,其中包括16%的CrD患者和9%的UC患者(CrD vs. UC,

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    2017-09-11 139****5926

    好好文章学习了

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