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Oncol Rep:首都医科大学贾继东等发现肝细胞癌的TP53突变与HCV阳性相关

2013-05-09 Oncol Rep dxy

Oncology Reports(《肿瘤学报告》)杂志2013年4月26日在线版发表了我国首都医科大学北京友谊医院肝病中心贾继东教授等人的一项最新研究结果。研究人员通过对116例肝细胞癌(HCC)中TP53基因突变情况的筛查,发现了TP53基因的一种新微插入缺失突变(microindel)突变,而且证明了伴有HCV感染的HCC通常与TP53基因的失活突变相关。尽管已知慢性丙型肝炎病毒(HCV)感染

Oncology Reports(《肿瘤学报告》)杂志2013年4月26日在线版发表了我国首都医科大学北京友谊医院肝病中心贾继东教授等人的一项最新研究结果。研究人员通过对116例肝细胞癌(HCC)中TP53基因突变情况的筛查,发现了TP53基因的一种新微插入缺失突变(microindel)突变,而且证明了伴有HCV感染的HCC通常与TP53基因的失活突变相关。
尽管已知慢性丙型肝炎病毒(HCV)感染可能会促进肿瘤的发生和发展,但其导致肝细胞癌的具体分子过程尚不为人知。Microindel是一种独特的、罕见的突变,导致同一核酸位点发生序列的插入或缺失,是肿瘤发生发展的重要“功臣”。迄今为止,还没有研究对肿瘤中TP53(p53 tumor suppressor gene,抑癌基因p53)的microindel突变进行彻底的检测。因此,本研究采用单链构象多态性分析以及直接测序法来筛查116例HCC肿瘤中TP53基因(外显子5-8)的突变情况。
在1例伴有HCV感染的HCC中,研究人员鉴别出一种特殊类型的TP53突变——616ins14del1(14-1 microindel)。TP53这一罕见的microindel突变会产生一个由211个氨基酸组成的截短蛋白,该蛋白缺少DNA结合域和四聚化结构域。免疫组织化学结果表明,该肿瘤细胞不表达p53蛋白,同时p21WAF/CIP、Mdm2和Bax水平也下调,提示p53信号通路受损。在116例HCC中,有19例(16.4%)携带TP53突变(共19种突变)。值得注意的是,在13例HCV阳性的病患中,有5例(38.5%)TP53发生突变,而且TP53突变与HCV阳性存在显著相关(P=0.0379)。没有观察到TP53突变与HBV(乙型肝炎病毒)阳性之间存在相关性。
综上所述,研究人员在HCC中发现一种新型的TP53 microindel突变,而且证明了伴有HCV感染的HCC通常与TP53基因的失活突变相关。
肝细胞癌相关的拓展阅读:


Correlation of TP53 mutations with HCV positivity in hepatocarcinogenesis: Identification of a novel TP53 microindel in hepatocellular carcinoma with HCV infection.

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    2013-09-30 xjy02
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    2013-09-19 minlingfeng
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1923088, encodeId=71ad192308830, content=<a href='/topic/show?id=97f835221ba' target=_blank style='color:#2F92EE;'>#医科大学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35221, encryptionId=97f835221ba, topicName=医科大学)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/fa8I6JticHgohY5FSGE98I1F4gpCjrpl2nbN6jZJY6JEqAjUibjItOA9AsgbBwTuBzAPbU5Tl8DxfemWUFFzBOYw/132, createdBy=24c12500054, createdName=ms2186806800017884, createdTime=Sat Apr 12 00:37:00 CST 2014, time=2014-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863206, encodeId=4364186320620, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Mon Sep 30 08:37:00 CST 2013, time=2013-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864444, encodeId=5d6f186444448, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Thu Sep 19 05:37:00 CST 2013, time=2013-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978358, encodeId=f1e419e8358b8, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Mon Jul 29 13:37:00 CST 2013, time=2013-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257565, encodeId=6682125e565e1, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Sat May 11 05:37:00 CST 2013, time=2013-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372348, encodeId=df6113e234866, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13627, encryptionId=9d861362e53, topicName=p53)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Sat May 11 05:37:00 CST 2013, time=2013-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458432, encodeId=a23014584324b, content=<a href='/topic/show?id=50a81e6869e' target=_blank style='color:#2F92EE;'>#TP53#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17686, encryptionId=50a81e6869e, topicName=TP53)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d276073420, createdName=zblhy, createdTime=Sat May 11 05:37:00 CST 2013, time=2013-05-11, status=1, ipAttribution=)]
    2013-05-11 ymljack
  6. [GetPortalCommentsPageByObjectIdResponse(id=1923088, encodeId=71ad192308830, content=<a href='/topic/show?id=97f835221ba' target=_blank style='color:#2F92EE;'>#医科大学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35221, encryptionId=97f835221ba, topicName=医科大学)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/fa8I6JticHgohY5FSGE98I1F4gpCjrpl2nbN6jZJY6JEqAjUibjItOA9AsgbBwTuBzAPbU5Tl8DxfemWUFFzBOYw/132, createdBy=24c12500054, createdName=ms2186806800017884, createdTime=Sat Apr 12 00:37:00 CST 2014, time=2014-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863206, encodeId=4364186320620, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Mon Sep 30 08:37:00 CST 2013, time=2013-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864444, encodeId=5d6f186444448, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Thu Sep 19 05:37:00 CST 2013, time=2013-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978358, encodeId=f1e419e8358b8, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Mon Jul 29 13:37:00 CST 2013, time=2013-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257565, encodeId=6682125e565e1, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Sat May 11 05:37:00 CST 2013, time=2013-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372348, encodeId=df6113e234866, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13627, encryptionId=9d861362e53, topicName=p53)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Sat May 11 05:37:00 CST 2013, time=2013-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458432, encodeId=a23014584324b, content=<a href='/topic/show?id=50a81e6869e' target=_blank style='color:#2F92EE;'>#TP53#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17686, encryptionId=50a81e6869e, topicName=TP53)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d276073420, createdName=zblhy, createdTime=Sat May 11 05:37:00 CST 2013, time=2013-05-11, status=1, ipAttribution=)]
    2013-05-11 zhishijing
  7. [GetPortalCommentsPageByObjectIdResponse(id=1923088, encodeId=71ad192308830, content=<a href='/topic/show?id=97f835221ba' target=_blank style='color:#2F92EE;'>#医科大学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35221, encryptionId=97f835221ba, topicName=医科大学)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/fa8I6JticHgohY5FSGE98I1F4gpCjrpl2nbN6jZJY6JEqAjUibjItOA9AsgbBwTuBzAPbU5Tl8DxfemWUFFzBOYw/132, createdBy=24c12500054, createdName=ms2186806800017884, createdTime=Sat Apr 12 00:37:00 CST 2014, time=2014-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863206, encodeId=4364186320620, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Mon Sep 30 08:37:00 CST 2013, time=2013-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864444, encodeId=5d6f186444448, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Thu Sep 19 05:37:00 CST 2013, time=2013-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978358, encodeId=f1e419e8358b8, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Mon Jul 29 13:37:00 CST 2013, time=2013-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257565, encodeId=6682125e565e1, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Sat May 11 05:37:00 CST 2013, time=2013-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372348, encodeId=df6113e234866, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13627, encryptionId=9d861362e53, topicName=p53)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Sat May 11 05:37:00 CST 2013, time=2013-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458432, encodeId=a23014584324b, content=<a href='/topic/show?id=50a81e6869e' target=_blank style='color:#2F92EE;'>#TP53#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17686, encryptionId=50a81e6869e, topicName=TP53)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d276073420, createdName=zblhy, createdTime=Sat May 11 05:37:00 CST 2013, time=2013-05-11, status=1, ipAttribution=)]
    2013-05-11 zblhy
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