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CLIN CHEM:晚期糖基化终末产物与糖尿病和心脏代谢危险因素的关系如何?

2017-06-09 MedSci MedSci原创

晚期糖基化终末产物(AGEs)及其受体被认为是糖尿病并发症发展的重要原因,但以前研究中它与糖尿病和心脏代谢结果的关系尚未理清。近日,国际杂志 《CLIN CHEM》上在线发表一项关于基于社区的队列中AGE-CML,sTAGE和sTAGE与糖尿病和心脏代谢危险因素的横断面分析的研究。

晚期糖基化终末产物(AGEs)及其受体被认为是糖尿病并发症发展的重要原因,但以前研究中它与糖尿病和心脏代谢结果的关系尚未理清。近日,国际杂志 《CLIN CHEM》上在线发表一项关于基于社区的队列中AGE-CMLsTAGEsTAGE糖尿病和心脏代谢危险因素的横断面分析的研究。

研究人员使用ELISA方法测量了来自社区动脉粥样硬化风险的1874名参与者中的N6 - 羧甲基赖氨酸(AGE-CML),AGEs的可溶性受体(sRAGE)和AGEs的内源性分泌受体(esRAGE)。研究人员进行了横断面分析,以评估这些生物标志物与编码RAGEAGER(高级糖基化终产物特异性受体)的基因的人口统计学,糖尿病,高血糖症,心脏代谢测量和基因变异的关联。

调整人口统计学和体重指数(BMI)后,糖尿病或血红蛋白A 1c AGE-CMLsRAGEesRAGE无显著性差异。黑人种族和AGER遗传变异与sRAGEesRAGE之间的差异有显著相关性,即便在调整后依然如此。[sRAGE中黑人vs白人的差异百分比(95CI):-29.17-34.86-23.48),esRAGE-26.97-33.11 -20.84; rs2070600sRAGE-30.13-40.98-19.29)和esRAGE-30.32-42.42-18.21; rs2071288sRAGE-20.03-34.87-5.18),esRAGE-37.70-55.75-19.65]。估计肾小球滤过率和蛋白尿与sRAGEesRAGE显著相关。BMIC反应蛋白与AGE-CMLsRAGEesRAGE负相关。AGE-CML与果糖胺和糖化白蛋白有一定相关。

与基于社区的人群中的糖尿病相比,AGE-CMLsRAGEesRAGE与遗传,肾脏和炎症反应相关性更高。研究结果表明,使用ELISA测试这些生物标志物并评估此类化合物在糖尿病中的作用方面缺乏特异性且价值有限。

原始出处:

Stephanie J. Loomis, Yuan Chen, David B. Sacks, Cross-sectional Analysis of AGE-CML, sRAGE, and esRAGE with Diabetes and Cardiometabolic Risk Factors in a Community-Based Cohort.Clinical Chemistry May 2017, 63 (5) 980-989; DOI: 10.1373/clinchem.2016.264135

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    2017-06-11 lfyang
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  4. [GetPortalCommentsPageByObjectIdResponse(id=1318285, encodeId=11a01318285df, content=<a href='/topic/show?id=b5dde6644b1' target=_blank style='color:#2F92EE;'>#糖基化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76644, encryptionId=b5dde6644b1, topicName=糖基化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43cb463, createdName=lfyang, createdTime=Sun Jun 11 13:24:00 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337177, encodeId=9524133e1778b, content=<a href='/topic/show?id=f4c251404aa' target=_blank style='color:#2F92EE;'>#心脏代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51404, encryptionId=f4c251404aa, topicName=心脏代谢)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Sun Jun 11 13:24:00 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531953, encodeId=65ab1531953a6, content=<a href='/topic/show?id=a5d55140684' target=_blank style='color:#2F92EE;'>#心脏代谢危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51406, encryptionId=a5d55140684, topicName=心脏代谢危险因素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c312300576, createdName=yang0214, createdTime=Sun Jun 11 13:24:00 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209145, encodeId=647a209145e9, content=学习了。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=28d72072417, createdName=我是谁??, createdTime=Sun Jun 11 00:22:43 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208884, encodeId=14952088840c, content=感动你好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sat Jun 10 08:00:29 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208815, encodeId=a4932088159c, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jun 10 06:43:48 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208733, encodeId=1b8c208e33aa, content=讲得很不错,值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Fri Jun 09 23:21:29 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208728, encodeId=7422208e28c1, content=学了。。。。。。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Fri Jun 09 22:50:01 CST 2017, time=2017-06-09, status=1, ipAttribution=)]
    2017-06-11 我是谁??

    学习了。。。

    0

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    2017-06-10 thlabcde

    感动你好东西学习了!

    0

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    2017-06-10 Y—xianghai

    学习了新知识

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1318285, encodeId=11a01318285df, content=<a href='/topic/show?id=b5dde6644b1' target=_blank style='color:#2F92EE;'>#糖基化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76644, encryptionId=b5dde6644b1, topicName=糖基化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43cb463, createdName=lfyang, createdTime=Sun Jun 11 13:24:00 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337177, encodeId=9524133e1778b, content=<a href='/topic/show?id=f4c251404aa' target=_blank style='color:#2F92EE;'>#心脏代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51404, encryptionId=f4c251404aa, topicName=心脏代谢)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Sun Jun 11 13:24:00 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531953, encodeId=65ab1531953a6, content=<a href='/topic/show?id=a5d55140684' target=_blank style='color:#2F92EE;'>#心脏代谢危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51406, encryptionId=a5d55140684, topicName=心脏代谢危险因素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c312300576, createdName=yang0214, createdTime=Sun Jun 11 13:24:00 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209145, encodeId=647a209145e9, content=学习了。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=28d72072417, createdName=我是谁??, createdTime=Sun Jun 11 00:22:43 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208884, encodeId=14952088840c, content=感动你好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sat Jun 10 08:00:29 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208815, encodeId=a4932088159c, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jun 10 06:43:48 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208733, encodeId=1b8c208e33aa, content=讲得很不错,值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Fri Jun 09 23:21:29 CST 2017, time=2017-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208728, encodeId=7422208e28c1, content=学了。。。。。。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Fri Jun 09 22:50:01 CST 2017, time=2017-06-09, status=1, ipAttribution=)]
    2017-06-09 131****2916

    讲得很不错,值得一读

    0

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    2017-06-09 135****7952平儿

    学了。。。。。。。。。。。

    0

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