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Neurology:帕金森病患者视觉和嗅觉交叉模式受损!

2018-02-08 xing.T MedSci原创

由此可见,这些发现表明由于后部壳核缺陷会导致PD患者的视觉/嗅觉的跨模式功能受损。这种交叉模式功能障碍可以作为PD新先兆评估的基础。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在明确帕金森病(PD)是否会影响视觉和嗅觉的交叉模式功能,因为PD可以损害各种认知功能,包括嗅觉。

研究人员进行了一系列行为实验,通过比较患者和年龄匹配的正常对照者(NCs)的表现来明确PD对交叉模式功能的影响。研究人员通过操纵图片/添味剂之间的语义联系来展示对气味的强度和偏好的视觉效果。此外,研究人员使用脑部成像来确定纹状体突触前多巴胺转运蛋白(DaT)缺失的作用。

进行分析,研究人员发现PD参与者的气味评估不受视觉信息的影响,而NCs在观看愉快/不愉快的视觉线索时,嗅探无味的液体闻出了气味。此外,在DaT缺失的纹状体中,尤其是后部壳核,与PD参与者的较少的视觉效应相关。

由此可见,这些发现表明由于后部壳核缺陷会导致PD患者的视觉/嗅觉的跨模式功能受损。这种交叉模式功能障碍可以作为PD新先兆评估的基础。

原始出处:

Motoyasu Honma,et al. Impairment of cross-modality of vision and olfaction in Parkinson disease.Neurology. 2018. https://doi.org/10.1212/WNL.0000000000005110

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    2018-03-09 yinhl1978
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    2018-02-10 zywlvao
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