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Stroke: 预测急性缺血性卒中早期死亡的指标

2019-02-17 不详 MedSci原创

目前随着研究进展,我们已知若干风险因素会增加缺血性卒中患者的中期和长期死亡率。但是早期卒中死亡率预测因子目前还没有人进行研究,然而这在临床实践中经常需要。因此,本项研究的目的是开发一种快速适用的预测模型用于预测卒中早期死亡风险。

背景和目的
目前随着研究进展,我们已知若干风险因素会增加缺血性卒中患者的中期和长期死亡率。但是早期卒中死亡率预测因子目前还没有人进行研究,然而这在临床实践中经常需要。因此,本项研究的目的是开发一种快速适用的预测模型用于预测卒中早期死亡风险。

方法
研究人员使用来自奥地利卒中登记处的数据和多变量逻辑回归分析来确定与缺血性卒中患者早期(卒中后≤7天)死亡率相关临床变量。然后使用这些变量来开发预测的缺血性卒中评分的早期死亡率的模型。

结果
总共有77653名缺血性卒中患者被纳入分析(中位年龄:74岁,47%为女性)。卒中的总死亡率为2%,死亡患者的中位数为3天。卒中量表,卒中前功能障碍(改良Rankin量表> 0),既往心脏病,糖尿病,后循环卒中综合征和非腔隙性卒中因素测量的年龄,卒中严重程度均与死亡率相关。以此构建预测模型其曲线下面积为0.879(95%CI,0.871-0.886),验证样品中为0.884(95%CI,0.863-0.905)。评分≥10的患者在卒中的首次7天内死亡的风险为35%(95%CI,28%-43%)。

结论
本项研究开发出一个简单的评分模型来评估缺血性卒中患者的早期死亡风险,评分大于10分的患者第一天死亡风险高达35%。

原始出处:
Thomas Gattringer. Et al. Predicting Early Mortality of Acute Ischemic Stroke. Stroke. 2019.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

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    2019-04-08 123fdaa8m88暂无昵称

    学习了,不错

    0

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    2019-02-17 123ba698m96暂无昵称

    飘过

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1973254, encodeId=022619e3254db, content=<a href='/topic/show?id=7cc35939955' target=_blank style='color:#2F92EE;'>#早期死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59399, encryptionId=7cc35939955, topicName=早期死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Sat Jun 01 09:29:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806316, encodeId=acdb18063160a, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Mon Jan 20 12:29:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893154, encodeId=f49e189315465, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Mon Aug 26 19:29:00 CST 2019, time=2019-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364311, encodeId=f7e7364311ea, content=学习了,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ab02453675, createdName=123fdaa8m88暂无昵称, createdTime=Mon Apr 08 16:19:43 CST 2019, time=2019-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360885, encodeId=c65c360885c0, content=飘过, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd5c2431968, createdName=123ba698m96暂无昵称, createdTime=Sun Feb 17 23:15:51 CST 2019, time=2019-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026299, encodeId=cefa102629945, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Feb 17 22:29:00 CST 2019, time=2019-02-17, status=1, ipAttribution=)]
    2019-02-17 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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