Cell Rep：如何开启DNA修复延缓机体衰老和疾病的发生？

2016-09-13 佚名生物谷

图片来源：www.phys.org 近日，一项刊登在国际杂志Cell Reports上的研究报告中，来自美国罗彻斯特大学的研究人员在寻找激活SIRT6的机制时，他们将化学抑制剂应用于人类皮肤细胞中来确定到底哪种蛋白质对于修复破碎的DNA链非常关键，结果研究者发现了一种关键蛋白c-Jun氨基末端激酶(JNK)，该蛋白能够激活基因对氧化性应激的反应，当JNK被抑制时，SIRT6就不会被激活，而且破碎

图片来源：www.phys.org

近日，一项刊登在国际杂志Cell Reports上的研究报告中，来自美国罗彻斯特大学的研究人员在寻找激活SIRT6的机制时，他们将化学抑制剂应用于人类皮肤细胞中来确定到底哪种蛋白质对于修复破碎的DNA链非常关键，结果研究者发现了一种关键蛋白c-Jun氨基末端激酶(JNK)，该蛋白能够激活基因对氧化性应激的反应，当JNK被抑制时，SIRT6就不会被激活，而且破碎的DNA链也不会被有效地修复。

为了在细胞内部传递压力信号，JNKs会将磷酸基团添加到蛋白质上，研究者发现，JNK能够修饰SIRT6上的氨基酸残基，一旦被修饰，SIRT6就能够将PARP1酶吸引到DNA的损伤位点中，在损伤位点处PARP1就能会进行一系列化学过程来修复DNA；实际上，激活的基因能够充当第一响应者来将DNA修复酶类招募到事故位点并且促进其发挥DNA修复的过程。

研究者Gorbunova表示，这项研究中我们揭示了机体老化过程发生的分子机制，此前研究中我们通过研究阐明了机体在以后生活中出现的“次级”DNA修复过程，同时还揭示了跳跃基因如何保持无活性状态。理解机体老化的分子、化学及遗传过程对于个体保持长寿以及较好的生活质量非常关键，当然后期还需要进行更多的研究以及临床实践，而且这对于开发新型抗衰老疗法也至关重要。

最后研究者表示，本文的研究结果还能够帮助制药研究者未来设计新型药物来激活SIRT6从而降低机体DNA的损伤过程；这些药物或许能够被用来保护机体基因组免受损伤，当然也能够抑制癌症及其它疾病的发生，并且延长个体的健康寿命。

原始出处

Michael Van Meter, Matthew Simon, Gregory Tombline, Alfred May, Timothy D. Morello, Basil P. Hubbard, Katie Bredbenner, Rosa Park, David A. Sinclair, Vilhelm A. Bohr, Vera Gorbunova4, Andrei Seluanov.JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.Cell Rep.2016

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2017-06-25 我爱光明2009

很有研究前景

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2016-09-13 维他命

#CEL#

87 0
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2017-03-15 仁医06

#Cell#

83 0
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2016-09-15 jambiya

#DNA修复#

61 0
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2016-09-14 青龙偃月

学习了，赞一个！

146 0
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2016-09-14 青龙偃月

学习了，赞一个！

131 0
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2016-09-14 青龙偃月

学习了，赞一个！

146 0
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2016-09-14 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！！

102 0
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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzSEB4Gw5zzMTFicSXpRPB29ZqXZWCwpKGlNQClGxQkM0V13y0nwwfOibuwhkgK3VibicMKbKcMSUzTzp/0, createdBy=e5131935950, createdName=1e0dde21m68(暂无匿称), createdTime=Tue Sep 13 20:19:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
2016-09-14 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！！

73 0
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2016-09-13 1e0dde21m68(暂无匿称)

这种修复是异源重组修复么？如果是的话，会增加细胞突变频率，诱发癌症的！

82 0

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Cell Rep：如何开启DNA修复延缓机体衰老和疾病的发生？