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JCEM:男性和绝经后女性性激素水平与心力衰竭的关联

2020-08-09 MedSci原创 MedSci原创

在这一前瞻性队列研究中,男性内源性睾丸激素和DHEA-S水平较低,绝经后女性中DHEA-S水平较低与HF的发生有关。这表明无论性别,性激素均通过常见途径在HF发生中发挥作用。

心力衰竭(HF)表型存在性别差异,但是关于性激素在HF及其亚型中作用的研究有限。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在评估总睾丸激素、硫酸脱氢表雄酮(DHEA-S)和性激素结合球蛋白(SHBG)与总的HF、射血分数正常HF(HFpEF)和射血分数降低HF(HFrEF)之间的关联。

该研究以社区中的动脉粥样硬化风险(ARIC)研究(前瞻性队列研究)为基础。中位随访时间为19.2年。参加者为4107名男性,4839名绝经后女性,平均年龄分别为63.2(SD为5.7)和62.8(5.5)岁。在第4次随访(1996-1998)时测量血浆中性激素水平。该研究地主要观察指标为通过医院出院代码和死亡证明来确定的HF。

男性总睾丸激素、DHEA-S和SHBG每降低1个SD相关的HF发生HR分别为1.10(95%CI为1.03,1.17)、1.07(1.00,1.15)和1.04(0.96,1.11),女性分别为1.05(0.99,1.13)、1.17(1.09,1.24)和0.93(0.85,1.01)。性激素与HF亚型之间的关联具有相似的类型,但有所减弱,并且在统计学上不显著。

在这一前瞻性队列研究中,男性内源性睾丸激素和DHEA-S水平较低,绝经后女性中DHEA-S水平较低与HF的发生有关。男性女性以及两种HF亚型关联的方向相类似,这表明无论性别,性激素均通过常见途径在HF发生中发挥作用。

原始出处:

Di Zhao,et al.Sex Hormones and Incident Heart Failure in Men and Post-Menopausal Women: The Atherosclerosis Risk in Communities Study.JCEM.2020.https://doi.org/10.1210/clinem/dgaa500

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    2020-08-20 xiaoo小

    好棒

    0

  5. 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  6. 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  7. 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  8. [GetPortalCommentsPageByObjectIdResponse(id=2063351, encodeId=acc720633512c, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Mon Mar 08 18:09:29 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777969, encodeId=ea6f1e7796915, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdAvatar=https://img.medsci.cn/20200820/5ae2b38e49364107958540e93f25fc38/17817c1718214c1497ea401ef5f17056.jpg, createdBy=15f85410064, createdName=xiaoo小, createdTime=Thu Aug 20 10:58:58 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257251, encodeId=cfe0125e25130, content=<a href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Tue Aug 11 14:09:29 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1286403, encodeId=eae6128640398, content=<a href='/topic/show?id=24395268347' target=_blank style='color:#2F92EE;'>#性激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52683, encryptionId=24395268347, topicName=性激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Tue Aug 11 14:09:29 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1526653, encodeId=c10e15266535c, content=<a href='/topic/show?id=2fe6e88863a' target=_blank style='color:#2F92EE;'>#绝经后女性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78886, encryptionId=2fe6e88863a, topicName=绝经后女性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b55511745984, createdName=chenhongpeng, createdTime=Tue Aug 11 14:09:29 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631635, encodeId=357b1631635f1, content=<a href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Tue Aug 11 14:09:29 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807189, encodeId=ca9480e18947, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/fb49ede2bc714e14abb1a1024e3f6969/ca936d1263ab48ffba726dafc70bcdb2.jpg, createdBy=92c35391508, createdName=ms4000001242976819, createdTime=Mon Aug 10 07:59:18 CST 2020, time=2020-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807163, encodeId=f3b980e16378, content=要注意身体, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200809/02bca699411a46a0a4c2338177f02c2a/abe25709fa61480f9f7bab3c955e6757.jpg, createdBy=18b31627402, createdName=zl1985, createdTime=Sun Aug 09 23:37:27 CST 2020, time=2020-08-09, status=1, ipAttribution=)]
    2020-08-11 zxxiang
  9. [GetPortalCommentsPageByObjectIdResponse(id=2063351, encodeId=acc720633512c, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Mon Mar 08 18:09:29 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777969, encodeId=ea6f1e7796915, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Mon Feb 15 16:09:29 CST 2021, time=2021-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1998330, encodeId=d5e919983304d, content=<a href='/topic/show?id=499c6683554' target=_blank style='color:#2F92EE;'>#激素水平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66835, encryptionId=499c6683554, topicName=激素水平)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Fri Apr 30 11:09:29 CST 2021, time=2021-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=811364, encodeId=7f6d81136461, content=好棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52683, encryptionId=24395268347, topicName=性激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Tue Aug 11 14:09:29 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1526653, encodeId=c10e15266535c, content=<a href='/topic/show?id=2fe6e88863a' target=_blank style='color:#2F92EE;'>#绝经后女性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78886, encryptionId=2fe6e88863a, topicName=绝经后女性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b55511745984, createdName=chenhongpeng, createdTime=Tue Aug 11 14:09:29 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631635, encodeId=357b1631635f1, content=<a href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Tue Aug 11 14:09:29 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807189, encodeId=ca9480e18947, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/fb49ede2bc714e14abb1a1024e3f6969/ca936d1263ab48ffba726dafc70bcdb2.jpg, createdBy=92c35391508, createdName=ms4000001242976819, createdTime=Mon Aug 10 07:59:18 CST 2020, time=2020-08-10, status=1, ipAttribution=), 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    2020-08-10 ms4000001242976819

    学习了

    0

  10. 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    2020-08-09 zl1985

    要注意身体

    0

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