Am Heart J：45岁以上中老年患者中，BNP是肺动脉高压患者死亡率或肺移植的有力预测因素

2022-08-06 MedSci原创 MedSci原创

肺动脉高压（PAH）是一种不常见的疾病，其特点是肺血管重塑，导致肺血管阻力（PVR）增加，造成肺动脉压力增加。在PAH患者的风险分层中，既往研究已经对多种生物标志物进行了调查。

肺动脉高压（PAH）是一种不常见的疾病，其特点是肺血管重塑，导致肺血管阻力（PVR）增加，造成肺动脉压力增加。在PAH患者的风险分层中，既往研究已经对多种生物标志物进行了调查。近日，发表于Am Heart J的一项系统综述和荟萃分析首次研究了（NT-pro）BNP对PAH患者的预后价值。

研究人员使用MEDLINE、Embase、Web of Science、Cochrane图书馆和Google scholar进行系统性文献检索，以确定PAH中基线（NT-pro）BNP水平的预后价值的研究。纳入报告死亡率或肺移植终点的危险比（HR）的研究。进行随机效应荟萃分析，计算诊断时（NT-pro）BNP水平的集合HR。为了说明应用于(NT-pro)BNP的不同转换，对于报告基于连续(NT-pro)BNP测量的HR的研究，计算了加权平均(NT-pro)BNP水平247pmol/L的2倍差异的HR。

结果，共纳入16项研究，包括6999名中老年患者（平均年龄45.2-65.0岁，97.3%为PAH）。总的来说，1460名患者在1至10年的平均随访期内达到终点。9项研究报告了基于截止值的HRs。荟萃分析结果显示，NT-proBNP和BNP升高时，死亡或肺移植的风险增加，基于未调整的HRs的集合HRs分别为2.75（95%-CI：1.86-4.07）和3.87（95% CI 2.69-5.57）。六项研究报告了(NT-pro)BNP的继续规模的HR。加权平均NT-proBNP的2倍差异导致死亡或肺移植的风险增加，集合HR为1.17（95%-CI：1.03-1.32）。

综上所述，该研究结果表明，(NT-pro)BNP水平的增加与PAH患者死亡或肺移植的风险明显增加有关。因此，在诊断时，NT-proBNP和BNP是PAH患者死亡率或肺移植的有力预测因素。测量（NT-pro）BNP应该是PAH临床护理和风险分层的基石。

原始出处：

Paul M Hendriks, et al., Prognostic value of brain natriuretic peptides in patients with pulmonary arterial hypertension: A systematic review and meta-analysis. Am Heart J. 2022 Aug;250:34-44. doi: 10.1016/j.ahj.2022.05.006.

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2023-05-28 zhmscau

#45岁#

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2023-04-18 naiwu77

#肺动脉高压患者#

102 0
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2023-01-25 仁者大医

#患者死亡#

68 0
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2022-09-14 more is better!

#中老年#

84 0
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2023-02-09 jklm09

#动脉高压#

71 0
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2022-07-31 朱睿睿

#预测因素#

0 0
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2022-07-31 huiwelcome

#BNP#

79 0
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2022-07-31 zhaojie88

#ART#

95 0
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2022-07-31 slcumt

#HEART#

97 0

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Am Heart J：45岁以上中老年患者中，BNP是肺动脉高压患者死亡率或肺移植的有力预测因素

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