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中国循环杂志:郑大一院学者研究显示,多索茶碱可有效治疗替格瑞洛所致呼吸困难,且不影响抗血小板效应

2017-11-02 卢芳 中国循环杂志

随着替格瑞洛在临床的广泛应用,与其相关的呼吸困难也越来越引起关注。近期郑州大学附属第一医院韩战营等研究发现,对于这类患者给予多索茶碱治疗呼吸困难有效,而且不影响替格瑞洛抗血小板聚集作用。

随着替格瑞洛在临床的广泛应用,与其相关的呼吸困难也越来越引起关注。近期郑州大学附属第一医院韩战营等研究发现,对于这类患者给予多索茶碱治疗呼吸困难有效,而且不影响替格瑞洛抗血小板聚集作用。

研究显示,应用多索茶碱1天后,93%的患者呼吸困难明显缓解,远远高于安慰剂组的63%。而且治疗前后,血小板聚集率与安慰剂相似。

此外,在随访半年时,服用多索茶碱组与安慰剂组心原性死亡、心肌梗死卒中、出血等心血管不良事件的发生率也无差异。

研究者介绍说,替格瑞洛可以使细胞外腺苷水平升高,多索茶碱起效或是由于能对抗腺苷等呼吸道的收缩作用所致,但鉴于仍有部分患者呼吸困难未缓解,其中机制尚需进一步研究。

该研究共纳入服用替格瑞洛后出现相关呼吸困难的冠心病患者172人,其中86人早晚给予多索茶碱片各1片,服用5天;余者均为对照,给予安慰剂治疗。

原始出处:
刘亚梅,韩战营, 王徐乐, 等. 多索茶碱治疗替格瑞洛相关呼吸困难的安全性和有效性分析. 中国循环杂志, 2017, 32: 886-888.

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    2017-11-04 hbwxf
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  4. [GetPortalCommentsPageByObjectIdResponse(id=1281856, encodeId=824e1281856c2, content=<a href='/topic/show?id=21753963364' target=_blank style='color:#2F92EE;'>#呼吸困难#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39633, encryptionId=21753963364, topicName=呼吸困难)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Sat Nov 04 02:47:00 CST 2017, time=2017-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402332, encodeId=04961402332d4, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Sat Nov 04 02:47:00 CST 2017, time=2017-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619496, encodeId=d8871619496ff, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sat Nov 04 02:47:00 CST 2017, time=2017-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258060, encodeId=d2d525806073, content=很不错.学习了.值得分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Thu Nov 02 12:21:09 CST 2017, time=2017-11-02, status=1, ipAttribution=)]
    2017-11-02 明天会更好!

    很不错.学习了.值得分享!

    0

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