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JACC：大部分年轻心梗患者没有达到接受他汀类药物治疗的标准

2018-01-26 MedSci MedSci原创

心血管心梗他汀
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尽管重视对心梗的预防，然而心梗在年轻的成年人中的发病率仍较高。本研究纳入的患者信息来自YOUNG-MI注册数据库，纳入了年龄≤50岁的心梗患者，并有对应的内科专家对心梗进行诊断和分型，通过混合队列风险方程评估心梗前和心梗发生中动脉粥样硬化性心血管疾病的风险。最终，有1685名患者符合入选标准，有210名患者在心梗发生前已经接受了他汀类药物治疗，被排除在外。在剩下的1475名患者中，平均年龄为45岁

尽管重视对心梗的预防，然而心梗在年轻的成年人中的发病率仍较高。本研究纳入的患者信息来自YOUNG-MI注册数据库，纳入了年龄≤50岁的心梗患者，并有对应的内科专家对心梗进行诊断和分型，通过混合队列风险方程评估心梗前和心梗发生中动脉粥样硬化性心血管疾病的风险。最终，有1685名患者符合入选标准，有210名患者在心梗发生前已经接受了他汀类药物治疗，被排除在外。在剩下的1475名患者中，平均年龄为45岁，294名为女性，846名患者有ST段抬高型心梗。在1225名患者中至少有一个心血管疾病危险因素，所有患者的10年平均动脉粥样硬化性心血管疾病风险为4.8%（2.8%-8.0%）。根据2013年美国心脏病协会指南和2016年美国预防服务工作建议，仅有分别724 (49%) 和430 (29%)名患者符合他汀类药物治疗标准。在女性患者中更显着，有184名（63%）女性患者没有达到他汀类药物治疗标准，而男性为549 (46%) 名(p < 0.001)。研究结果显示，目前大部分年轻心梗患者并没有达到接受他汀类药物治疗的标准。原始出处：Avinainder S et al.Cardiovasc

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    2018-12-19 ms6390871039024434

    #他汀类药#

    0

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    2018-09-03 hbwxf

    #JACC#

    0

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channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Fri Jan 26 21:16:45 CST 2018, time=2018-01-26, status=1, ipAttribution=)]
    2018-10-19 zhanglin3079

    #心梗患者#

    0

  4. 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    2018-01-30 jyzxjiangqin

    年轻心梗患者的他汀治疗.

    0

  5. 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    2018-01-28 12498568m50暂无昵称

    #ACC#

    0

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    2018-01-26 天地飞扬

    家庭医生任重而道远

    0

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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Fri Jan 26 21:17:01 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282281, encodeId=e62f282281c8, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Fri Jan 26 21:16:53 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282280, encodeId=bd2e28228056, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Fri Jan 26 21:16:45 CST 2018, time=2018-01-26, status=1, ipAttribution=)]
    2018-01-26 1e0f8808m18(暂无匿称)

    规范治疗.防患未然.

    0

  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Fri Jan 26 21:17:01 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282281, encodeId=e62f282281c8, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Fri Jan 26 21:16:53 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282280, encodeId=bd2e28228056, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Fri Jan 26 21:16:45 CST 2018, time=2018-01-26, status=1, ipAttribution=)]
    2018-01-26 戒馋，懒，贪

    谢谢分享学习了

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue Jan 30 07:06:03 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325683, encodeId=84d313256836c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sun Jan 28 12:11:00 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282331, encodeId=ec052823313d, content=家庭医生任重而道远, beContent=null, objectType=article, 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channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Fri Jan 26 21:16:45 CST 2018, time=2018-01-26, status=1, ipAttribution=)]
    2018-01-26 戒馋，懒，贪

    谢谢分享学习了

    0

  10. 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channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Fri Jan 26 21:16:45 CST 2018, time=2018-01-26, status=1, ipAttribution=)]
    2018-01-26 戒馋，懒，贪

    谢谢分享学习了

    0

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Circulation： 心血管第一期刊：生酮饮食或又有新功能！科学家发现它可以改善心肌代谢，显著延缓心衰进展：科学大发现

近年来，生酮饮食在各大媒体上可谓是红到发紫。每隔一段时间，就会有关于生酮饮食的报道出来。当然，这种事情不能怪媒体跟风，只能怪生酮饮食功能的确太多了。

JACC：心梗后的炎性反应对大脑和心脏的功能有明显影响

急性心梗后的局部炎性组织反应对最后的预后结果起到重要作用，全身作用引起的神经性炎症是神经退行性疾病的前兆。本研究的目的旨在通过非侵入性的正电子发射断层扫描（PET）评估心梗对心脏和大脑炎性反应的影响。本研究在对小鼠进行冠脉结扎或者假手术处理后，对所有小鼠（n=49）进行了全身线粒体转运蛋白（TSPO）的PET扫描，TSPO作为标记激活巨噬细胞和小胶质细胞的标志物，同时，急性心梗后的病人（n=3）也

JAHA：2型糖尿病患者SGLT2抑制剂的心血管安全和长期非心血管疗效分析！

由此可见，SGLT2抑制剂表现出显著的心血管和肾脏保护作用，并且具有好的长期非心血管安全性和疗效。

CNS Drugs：帕金森病患者心血管自主神经功能障碍的药物治疗

美国科学家在《CNS Drugs》发表的一项综述，介绍了帕金森病患者心血管自主神经功能障碍的药物治疗。

JACC：应重视遗传性高胆固醇血症的早期诊断和治疗

常染色体隐性遗传性高胆固醇血症（ARH）是一类罕见的以脂代谢异常为主要特点的动脉粥样硬化性心血管疾病，目前对于ARH的治疗管理和远期预后的资料尚缺乏。本研究的目的旨在评估ARH患者脂质的变化、低密度脂蛋白胆固醇（LDL-C）的达标水平和远期预后。本研究搜集了52例ARH患者的临床资料（女性28例，平均年龄为31.1 ± 17.1岁，基线LDL-C水平为571.9 ± 171.7 mg/dl)）。经

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