Baidu
map

神经科

订阅

MedSci主页 / 所有栏目 / 神经科

曙光初现：阻止或减缓阿尔茨海默症状出现的药物或已问世

2020-02-08 Allan MedSci原创

阿尔茨海默症BAN2401β-淀粉样蛋白
关注

美国南加州大学阿尔茨海默症治疗研究所（ATRI）的研究人员正准备在全球范围内寻找适合服用实验性药物BAN2401的候选人，BAN2401预计能够减缓并阻止阿尔茨海默症的进展。

美国南加州大学阿尔茨海默症治疗研究所（ATRI）的研究人员正准备在全球范围内寻找适合服用实验性药物BAN2401的候选人，BAN2401预计能够减缓并阻止阿尔茨海默症的进展。

ATRI负责人保罗·艾森说：“BAN2401能够清除大脑内的斑块，我们相信患者在遭受重大、不可逆转的损害之前，尽早服用该药物会有巨大好处”。ATRI正在与哈佛研究人员合作进行这项研究，该研究将在全球范围内招募患者，使用正电子发射断层扫描来确定BAN2401能否降低β-淀粉样蛋白水平。

阿尔茨海默的真正成因至今不明，目前将阿尔茨海默视为一种神经退化疾病，并认为有将近七成的风险因子与遗传有关，其他的风险因子还有头部外伤、忧郁症和高血压。疾病的进程与大脑中的纤维状β-淀粉样斑块沉积和Tau蛋白有关。


原始出处：

https://www.firstwordpharma.com/node/1699223

本文系梅斯医学（MedSci）原创编译整理，转载需授权!

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1818004, encodeId=b130181800403, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Mar 10 12:52:00 CST 2020, time=2020-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725185, encodeId=87091e251853e, content=<a href='/topic/show?id=58476021257' target=_blank style='color:#2F92EE;'>#曙光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60212, encryptionId=58476021257, topicName=曙光)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=180c33737541, createdName=yangpeizhi, createdTime=Sat Oct 24 20:52:00 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816981, encodeId=1599181698178, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Thu Jun 11 21:52:00 CST 2020, time=2020-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470358, encodeId=62da14e03586f, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Mon Feb 10 11:52:00 CST 2020, time=2020-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=379047, encodeId=409b3e9047f4, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAYdbqrgz1Oa9icrXIJSaPFtI6Wy17Hdcyh7THEZuQ8mpGcboCYTLdic26uTQg9tKoxFJDQIyPgvfQ/132, createdBy=1b722043878, createdName=jxncchina, createdTime=Sun Feb 09 10:19:22 CST 2020, time=2020-02-09, status=1, ipAttribution=)]
    2020-03-10 12498da4m32(暂无昵称)

    #阿尔茨海#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1818004, encodeId=b130181800403, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Mar 10 12:52:00 CST 2020, time=2020-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725185, encodeId=87091e251853e, content=<a href='/topic/show?id=58476021257' target=_blank style='color:#2F92EE;'>#曙光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60212, encryptionId=58476021257, topicName=曙光)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=180c33737541, createdName=yangpeizhi, createdTime=Sat Oct 24 20:52:00 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816981, encodeId=1599181698178, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Thu Jun 11 21:52:00 CST 2020, time=2020-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470358, encodeId=62da14e03586f, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Mon Feb 10 11:52:00 CST 2020, time=2020-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=379047, encodeId=409b3e9047f4, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAYdbqrgz1Oa9icrXIJSaPFtI6Wy17Hdcyh7THEZuQ8mpGcboCYTLdic26uTQg9tKoxFJDQIyPgvfQ/132, createdBy=1b722043878, createdName=jxncchina, createdTime=Sun Feb 09 10:19:22 CST 2020, time=2020-02-09, status=1, ipAttribution=)]
    2020-10-24 yangpeizhi

    #曙光#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1818004, encodeId=b130181800403, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Mar 10 12:52:00 CST 2020, time=2020-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725185, encodeId=87091e251853e, content=<a href='/topic/show?id=58476021257' target=_blank style='color:#2F92EE;'>#曙光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60212, encryptionId=58476021257, topicName=曙光)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=180c33737541, createdName=yangpeizhi, createdTime=Sat Oct 24 20:52:00 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816981, encodeId=1599181698178, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Thu Jun 11 21:52:00 CST 2020, time=2020-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470358, encodeId=62da14e03586f, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Mon Feb 10 11:52:00 CST 2020, time=2020-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=379047, encodeId=409b3e9047f4, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAYdbqrgz1Oa9icrXIJSaPFtI6Wy17Hdcyh7THEZuQ8mpGcboCYTLdic26uTQg9tKoxFJDQIyPgvfQ/132, createdBy=1b722043878, createdName=jxncchina, createdTime=Sun Feb 09 10:19:22 CST 2020, time=2020-02-09, status=1, ipAttribution=)]
    2020-06-11 ms1948154235210413

    #阿尔茨#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1818004, encodeId=b130181800403, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Mar 10 12:52:00 CST 2020, time=2020-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725185, encodeId=87091e251853e, content=<a href='/topic/show?id=58476021257' target=_blank style='color:#2F92EE;'>#曙光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60212, encryptionId=58476021257, topicName=曙光)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=180c33737541, createdName=yangpeizhi, createdTime=Sat Oct 24 20:52:00 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816981, encodeId=1599181698178, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Thu Jun 11 21:52:00 CST 2020, time=2020-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470358, encodeId=62da14e03586f, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Mon Feb 10 11:52:00 CST 2020, time=2020-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=379047, encodeId=409b3e9047f4, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAYdbqrgz1Oa9icrXIJSaPFtI6Wy17Hdcyh7THEZuQ8mpGcboCYTLdic26uTQg9tKoxFJDQIyPgvfQ/132, createdBy=1b722043878, createdName=jxncchina, createdTime=Sun Feb 09 10:19:22 CST 2020, time=2020-02-09, status=1, ipAttribution=)]
    2020-02-10 yhj-time

    #阿尔茨海默#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1818004, encodeId=b130181800403, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Mar 10 12:52:00 CST 2020, time=2020-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725185, encodeId=87091e251853e, content=<a href='/topic/show?id=58476021257' target=_blank style='color:#2F92EE;'>#曙光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60212, encryptionId=58476021257, topicName=曙光)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=180c33737541, createdName=yangpeizhi, createdTime=Sat Oct 24 20:52:00 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816981, encodeId=1599181698178, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Thu Jun 11 21:52:00 CST 2020, time=2020-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470358, encodeId=62da14e03586f, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Mon Feb 10 11:52:00 CST 2020, time=2020-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=379047, encodeId=409b3e9047f4, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJAYdbqrgz1Oa9icrXIJSaPFtI6Wy17Hdcyh7THEZuQ8mpGcboCYTLdic26uTQg9tKoxFJDQIyPgvfQ/132, createdBy=1b722043878, createdName=jxncchina, createdTime=Sun Feb 09 10:19:22 CST 2020, time=2020-02-09, status=1, ipAttribution=)]
    2020-02-09 jxncchina

    不错

    0

相关资讯

Neurology：膳食中黄酮醇摄入量与阿尔茨海默症的风险

由此可见，饮食中黄酮醇的摄入量增加可能会降低患阿尔茨海默氏痴呆症的风险。

锂能阻止阿尔茨海默症的进展吗？

时至今日，科学界仍在争论锂疗法在治疗阿尔茨海默症中的价值，这很大程度上是由于以下事实：由于迄今为止收集的信息是使用多种不同的方法、条件、制剂、治疗时间和剂量获得的，因此难以横向比较。

Sci Transl Med：阿尔茨海默症浮现新的诊断指标！

血脑屏障介导血管和大脑之间的信息交互，而衰老和神经系统疾病发生通常与血脑屏障损伤相关。动物实验表明血脑屏障损伤导致星型胶质细胞功能障碍、神经炎症、胞外基质组成变化、兴奋性突触增生，降低癫痫发作阈值，加速神经退行的产生。

绿谷药业宣布将在全球200个临床中心，开展阿尔茨海默症新药GV-971的全球临床试验

去年11月，中国批准了上海绿谷药业的阿尔茨海默氏症新药GV-971（甘露特纳胶囊）。 现在绿谷药业宣布GV-971将在北美，欧盟，东欧，亚太地区和其他地区的200个临床中心进行测试。

FDA批准：间充质干细胞治疗阿尔茨海默症的突破性临床试验

专注于开发细胞疗法的临床阶段生物技术公司Hope Biosciences近日宣布，FDA已批准I / II期临床试验，以评估自体脂肪来源的间充质干细胞（HB-adMSCs）治疗阿尔茨海默症的安全性和有效性。

Biogen将从辉瑞购买实验性阿尔茨海默症/帕金森病药物PF-05251749

Biogen公司本周一宣布，它将以超过7亿美元的价格从辉瑞公司收购实验药物PF-05251749。

Baidu
map
Baidu
map
Baidu
map