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SCI REP:定期运动改善糖尿病患者基因组稳定性!

2017-06-24 xing.T MedSci原创

最后,针对T2DM患者基因表达分析表明适应性反应延长的运动训练可以提高特定基因的反应。

体育活动已被证明在不同的慢性疾病中具有有效的预防和治疗作用,包括2型糖尿病(T2DM)。特别地是,有几项研究强调了体力活动的有益影响可能与DNA分子的稳定性有关,如较长的端粒末端。

近日,Scientific reports 杂志上发表了一篇研究文章,在这里,研究人员分析了运动训练对端粒长度、自发性和H2O2诱导的DNA损伤的影响,以及分析了来自于进行体育训练或不训练的T2DM患者与年龄匹配的对照者白细胞中的凋亡水平(57-66岁)。此外,还对DNA修复系统、细胞周期控制、抗氧化和防御系统中所选择的基因进行了表达分析。

研究人员发现参加常规运动项目的受试者端粒长度比未参加训练的受试者要长。此外,在体外采用H2O2处理白细胞,发现:(1)氧化性DNA损伤诱导了所有组类似的端粒损耗;(2)在T2DM的受试者中,体育活动似乎可以预防慢性暴露于氧化刺激引起的基因组DNA氧化损伤的显著增加,以及(3)减少白细胞对凋亡的灵敏度。

最后,针对T2DM患者基因表达分析表明适应性反应延长的运动训练可以提高特定基因的反应。

原始出处:

Ivan Dimauro,et al. Regular exercise participation improves genomic stability in diabetic patients: an exploratory study to analyse telomere length and DNA damage.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-04448-4

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    2017-06-25 ylzr123

    好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。

    0

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    2017-06-25 Julie W

    最后,针对T2DM患者基因表达分析表明适应性反应延长的运动训练可以提高特定基因的反应。

    0

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    2017-06-25 lou.minghong

    五驾马车之一

    0

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    2017-06-24 1e0f8808m18(暂无匿称)

    生命在于运动,运动治疗和预防慢病。

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    2017-06-24 dhzzm

    学习了分享了

    0

  8. 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    2017-06-24 浙江小强

    学习

    0

  9. 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    2017-06-24 Y—xianghai

    学习了新知识

    0

  10. 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    2017-06-24 186****0580(小山羊)

    学习了谢谢了。

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