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Nat Cell Biol:胰岛素注射时代或将终结!让糖尿病自我缓解!

2019-01-09 Michael 转化医学网

随着生活水平的不断提高,肥胖人群的不断增多导致糖尿病患者的人数也日益上升,而目前糖尿病的临床治疗主要分为3个阶段。首先,当患者的血糖水平在糖尿病诊断标准上下波动时,医生一般令患者加强体育锻炼,减少碳水化合物的摄入以及减重等方式进行干预。当空腹血糖水平一直大于7mmol/L,医生一般对患者进行药物干预治疗。当患者在药物干预之后其血糖水平仍没有得到有效的控制,此时则会进行胰岛素替代治疗。然而,近日来自

随着生活水平的不断提高,肥胖人群的不断增多导致糖尿病患者的人数也日益上升,而目前糖尿病临床治疗主要分为3个阶段。首先,当患者的血糖水平在糖尿病诊断标准上下波动时,医生一般令患者加强体育锻炼,减少碳水化合物的摄入以及减重等方式进行干预。当空腹血糖水平一直大于7mmol/L,医生一般对患者进行药物干预治疗。当患者在药物干预之后其血糖水平仍没有得到有效的控制,此时则会进行胰岛素替代治疗。然而,近日来自Geneva大学Pedro L. Herrera教授的研究团队胰腺细胞或可转化个“身份”进而自己扭转糖尿病病情,该研究的最新进展发表于《Nature Cell Biology》杂志。

Geneva大学的研究人员发现胰腺中产生胰高血糖素的细胞可以改变“身份”,进而逐渐替代周围周围受损胰岛素细胞的部分功能。Geneva大学临床科学系Luiza Ghila教授表示,“我们可能正面临一种全新的糖尿病治疗方式,糖尿病患者体内的某些胰腺细胞可以产生一定量的补充胰岛素,进而提供一些微弱的缓解作用”。

细胞身份“超级变变”

研究人员发现,胰腺中只有约2%的邻近细胞可以改变身份。然而,这些改变身份的细胞令研究者对潜在的新治疗方法产生了浓厚的兴趣。

研究人员首次描述了这种细胞“变身”背后的机制。事实证明,这并不是一个非常被动的过程,而是来自周围细胞信号的推动结果。在该研究中,研究人员能够使用影响细胞间信号传导过程的药物将胰岛素生成细胞的数量增加到5%,但该结果仅在动物模型中证明有效。

Ghila教授表示说,“如果我们对这种细胞“改变”的机制有更多的了解,那么我们就有可能控制这一奇特的过程并改变更多细胞的身份,进而可以产生更多的胰岛素,并达到缓解患者症状的水平”。

该“变身”机制可能并不仅限于胰腺细胞

研究人员表示,新发现不仅对当前的糖尿病治疗带来了全新的治疗理念,这种神奇的“变身”机制或可存在于机体的其他器官当中,因此探究其他组织器官中是否存在相似的机制将成为该团队接下来的研究重点。

Ghila教授表示“细胞改变身份和功能的能力可能是治疗那些由细胞死亡引起疾病的决定性发现,这些疾病包含我们所熟知的阿尔茨海默病和心脏病等,探究这种机制产生的内在机制将有利于其他研究者开发相应的药物,进而推动体内这一“变身”过程的出现 ”。

一旦这种机制其背后的机制被详尽明确,那么我们或可了解到机体自我修复关键机制之一,同时,利用这些机制开发针对不同组织不同疾病的靶向药物,将大大改善患者的预后,仅从糖尿病患者来看,这种药物的问世则可使广大糖尿病患者免受胰岛素注射的痛苦。

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    2019-05-17 sunylz
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    2019-04-23 baoya
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    2019-02-05 维他命
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    2019-01-09 misszhang

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