Arthritis Rheumatol：RA患者中HLA-DRB1*03与抗氨甲酰蛋白抗体的特异性关联

2018-10-02 xiangting MedSci原创

研究确定了HLA-DRB1*03与ACPA-/ACarPA+ RA的特异性关联，这表明了氨甲酰肽的优先出现可作为HLA导致RA易感性的新机制。

新的RA特异性自身抗体、抗氨甲酰蛋白抗体（ACarPA），为人们提供了改善RA治疗和了解RA的机会。然而，关于这些抗体仍存在许多问题，其中包括它们与HLA-DRB1等位基因的关系。

研究包括来自3个队列1126名RA患者的样本。通过ELISA测定体外针对氨甲酰FCS蛋白的血清反应性。通过杂交技术或来自HLA密集基因型的填补确定HLA-DRB1等位基因。这些结果通过meta分析与之前报道的3个队列的数据相结合。比较了ACPA/ACarPA分层的抗体阳性亚组与双阴性亚组之间、和4个患者分层与健康对照之间的常见HLA-DRB1等位基因的携带频率。

对3709名RA患者和2305名健康对照者进行了meta分析。研究发现与ACPA-/ACarPA-患者和健康对照比较，ACPA-/ACarPA+亚组中的HLA-DRB1*03携带者显著增多，这在6个样本集中是一致的。这种相关性与SE和分析的混杂因素无关。没有别的等位基因与ACPA-/ACarPA+患者特异性相关。与之相反，ACPA+/ACarPA-和ACPA+/ACarPA+患者亚组中的SE显著增加，而这些患者亚组之间没有区别。此外，一些等位基因（包括HLA-DRB1*03）与免于罹患ACPA+RA相关。

研究确定了HLA-DRB1*03与ACPA-/ACarPA+ RA的特异性关联，这表明了氨甲酰肽的优先出现可作为HLA导致RA易感性的新机制。

原始出处：

Cristina Regueiro. Specific association of HLA‐DRB1*03 with anti‐carbamylated protein antibodies in patients with RA. Arthritis Rheumatol. 01 October 2018.

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#插入话题

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2018-10-08 jinweidong

#特异性#

83 0
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2019-09-11 ms6390871039024434

#Arthritis#

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2019-04-12 w984445tii

#DRB1#

100 0
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2018-10-06 1e145228m78(暂无匿称)

学习了，谢谢作者分享!

89 0
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2018-10-04 zhaojie88

#ART#

69 0
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2018-10-04 marongnuan

#HLA#

62 0
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2018-10-04 lqrandywkz

#HLA-DRB1#

72 0
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2018-10-02 1e1b8538m79(暂无匿称)

不错的文章值得拥有哦

107 0

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