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isterra正式启动甲型流感药物VIS410的2期临床试验

2017-01-16 佚名 生物谷

VisterraVIS4102期临床实验
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Visterra已经正式启动流感药物VIS410的2a期临床试验，已经给第一个试验者给药进行治疗。这项临床试验将研究单克隆抗体药物VIS410治疗感染甲型流感住院病人的疗效，针对的病毒是任何种类的甲型流感病毒株。 这项全球的临床试验正在接近150个非卧床的甲型流感感染者身上进行试验，他们将把这些试验者随机分为3组，分别接受2000 mg或4000 mg的VIS410或者是安慰剂治疗。主要终点是安


Visterra已经正式启动流感药物VIS410的2a期临床试验，已经给第一个试验者给药进行治疗。这项临床试验将研究单克隆抗体药物VIS410治疗感染甲型流感住院病人的疗效，针对的病毒是任何种类的甲型流感病毒株。

这项全球的临床试验正在接近150个非卧床的甲型流感感染者身上进行试验，他们将把这些试验者随机分为3组，分别接受2000 mg或4000 mg的VIS410或者是安慰剂治疗。主要终点是安全性和病人耐受性，次要终点包括流感的临床症状、病毒学特征及VIS410的药代动力学。

这个临床试验由美国卫生及公共服务部、应急准备和反应部助理部长办公室、生物医学高级研究和发展署等部门资助，项目编号为HHSO100201500018C。

VIS410是一种靶向所有已知甲流病毒株的单克隆抗体，将用于治疗感染甲流的住院病人。它针对血细胞凝集素上的一个特殊表位，流感病毒可以通过结合细胞表面的血细胞凝集素，并进入细胞。

而这个药物可以通过结合血细胞凝集素来防止流感病毒与宿主细胞融合，从而终止病毒的复制，达到清除病毒治疗流感的目的。

原始出处：

Visterra doses first patient in phase 2a trial of influenza A candidate VIS410

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    2017-01-23 surilei

    #ERR#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1703581, encodeId=73601e0358184, content=<a href='/topic/show?id=0d2869594b' target=_blank style='color:#2F92EE;'>#ERR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6959, encryptionId=0d2869594b, topicName=ERR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a72d30527892, createdName=surilei, createdTime=Mon Jan 23 06:46:00 CST 2017, time=2017-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970249, encodeId=bad419e0249af, content=<a href='/topic/show?id=7cb11116d7' target=_blank style='color:#2F92EE;'>#2期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1116, encryptionId=7cb11116d7, topicName=2期临床)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Sat May 20 13:46:00 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531209, encodeId=4c0f1531209f9, content=<a href='/topic/show?id=244169e70f0' target=_blank style='color:#2F92EE;'>#甲型流感#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69770, encryptionId=244169e70f0, topicName=甲型流感)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=86ba12221972, createdName=redcrab, createdTime=Wed Jan 18 12:46:00 CST 2017, time=2017-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170800, encodeId=10d01e0800d3, content=优秀, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Mon Jan 16 23:35:37 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170798, encodeId=c1b11e07980d, content=第一个，哈哈。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/sp9HFtQXjmv7KvIaqDy1qMa7WNiaQhIq06LSXTojGjtTG418ibnmY9yU0VBHUhGWHgia6dk8hkUJx4zBrc2TMC6bA/132, createdBy=33051979095, createdName=黑哥哥, createdTime=Mon Jan 16 22:57:57 CST 2017, time=2017-01-16, status=1, ipAttribution=)]
    2017-05-20 ysjykql

    #2期临床#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1703581, encodeId=73601e0358184, content=<a href='/topic/show?id=0d2869594b' target=_blank style='color:#2F92EE;'>#ERR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6959, encryptionId=0d2869594b, topicName=ERR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a72d30527892, createdName=surilei, createdTime=Mon Jan 23 06:46:00 CST 2017, time=2017-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970249, encodeId=bad419e0249af, content=<a href='/topic/show?id=7cb11116d7' target=_blank style='color:#2F92EE;'>#2期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1116, encryptionId=7cb11116d7, topicName=2期临床)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Sat May 20 13:46:00 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531209, encodeId=4c0f1531209f9, content=<a href='/topic/show?id=244169e70f0' target=_blank style='color:#2F92EE;'>#甲型流感#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69770, encryptionId=244169e70f0, topicName=甲型流感)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=86ba12221972, createdName=redcrab, createdTime=Wed Jan 18 12:46:00 CST 2017, time=2017-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170800, encodeId=10d01e0800d3, content=优秀, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Mon Jan 16 23:35:37 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170798, encodeId=c1b11e07980d, content=第一个，哈哈。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/sp9HFtQXjmv7KvIaqDy1qMa7WNiaQhIq06LSXTojGjtTG418ibnmY9yU0VBHUhGWHgia6dk8hkUJx4zBrc2TMC6bA/132, createdBy=33051979095, createdName=黑哥哥, createdTime=Mon Jan 16 22:57:57 CST 2017, time=2017-01-16, status=1, ipAttribution=)]
    2017-01-18 redcrab

    #甲型流感#

    0

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    2017-01-16 䖝二

    优秀

    0

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    2017-01-16 黑哥哥

    第一个，哈哈。。

    0

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