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Dig Dis Sci: 质子泵抑制剂对小肠和粪便微生物群落的影响

2021-02-17 MedSci原创 MedSci原创

质子泵抑制剂(PPI)是使用最广泛的药物之一,在某些成年人中的使用率高达15.5%。

      质子泵抑制剂(PPI)是使用最广泛的药物之一,在某些成年人中的使用率高达15.5%。尽管最近的一项前瞻性研究表明,PPI与长期不良事件的风险显着增加无关,但PPI的使用会降低胃酸分泌,并且数据表明,这可能会影响肠道微生物组成。SIBO是由小肠中细菌数量异常和过多所导致的疾病,通常与胃肠道(GI)症状相关,例如腹胀,气体过多,腹部不适和腹泻以及体重减轻相关。一些推测认为PPI使用是SIBO的原因。因此,本项研究旨在比较PPI和非PPI用户的十二指肠和粪便微生物组的差异。

 

 

      为了进行这项研究,研究人员招募了不进行结肠镜检查连续受试者,使用抗生素的患者被排除在外。服用PPI的受试者与非PPI对照的年龄和性别匹配为1:2。通过16S rRNA测序分析患者十二指肠和粪便微生物的成分。

 

 

      研究结果显示十二指肠微生物组在PPI(N  = 59)和非PPI受试者(N  = 118)之间差异并不明显,但是在PPI受试者中,弯曲杆菌科(3.13倍,FDR P值<0.01)和双歧杆菌科(2.9倍,FDR P值<0.01)相对丰度明显更高,梭菌科的相对丰度较低(88.24倍,FDR P值<0.0001)。无论是通过细菌培养还是通过16S测序确定的,两组之间的SIBO率均无显着差异,采用不同PPI的受试者之间的SIBO率也无显着差异。

 

 

      这些发现表明,使用PPI与更高的SIBO率无关,但是会使十二指肠和粪便微生物组梭菌科的相对丰度降低,粪便中链球菌科的相对丰度增加。

 

 

原始出处:

Stacy Weitsman. Et al. Effects of Proton Pump Inhibitors on the Small Bowel and Stool Microbiomes. Digestive Diseases and Sciences.2021.

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    2021-08-25 zhaojie88
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    2021-06-22 jklm09
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    2021-02-18 Homburg

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