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Eur Urol:多参数核磁共振成像系统性忽略的前列腺癌类型研究

2020-05-22 AlexYang MedSci原创

所有的风险分层策略均会造成忽略一部分疾病。前列腺MR成像研究(PROMIS)为研究多参数核磁共振成像(mpMRI)忽略的癌症提供了途径。最近,有研究人员总结了被mpMRI系统性忽略的癌症属性。

所有的风险分层策略均会造成忽略一部分疾病。前列腺MR成像研究(PROMIS)为研究多参数核磁共振成像(mpMRI)忽略的癌症提供了途径。最近,有研究人员总结了被mpMRI系统性忽略的癌症属性。

在患有癌症的男性中,根据定义1(任何长度的格林森≥4+3或者任何等级的MCCL≥6mm),7%(17/230;95%CI 4.4-12%)的男性明显的被mpMRI系统性忽略;而根据定义2(任何长度的格林森≥3+4或者任何等级的MCCL≥4mm),13%(44/331;95% CI 9.8-17%)的男性被系统性忽略。根据定义1,TRUS指导的活检忽略了52%的显著疾病(119/230; 95% CI 45-58%),而定义2中忽略了40% (132/331; 95% CI 35-45%)。mpMRI未检测到的前列腺癌比检测到的具有显著更低的总体和最大格林森得分(p=0.0007; p<0.0001)和更短的MCCL(均差:3mm(5mm vs 8mm),p<0.0001;95%CI 1-3)。TPM活检的总格林森得分>3+4(格林森等级3-5;95%CI 0-6.4%)或者最大格林森得分>4+3(格林森等级组4-5;95% CI 0-8.0%)均被mpMRI检测到。使用0.15的PSAD阈值能够减少定义1中未检测到癌症比例到5%(12/230; 95% CI 2.7-8.9%);定义2中 到9% (30/331; 95% CI 6.2-13%) 。而使用0.10的PSAD阈值能够分别减少到3%(6/230; 95% CI 1.0-5.6%)和3%(11/331; 95% CI 1.7-5.9%)。研究的局限性为事后分析和未检测到的病变的不确定意义。

最后,研究人员指出,mpMRI忽略的癌症比例从4.4%到17%。mpMRI未检测到的癌症比检测到的癌症具有更低的等级和更短的长度。

原始出处:

Joseph M Norris , Lina M Carmona Echeverria , Simon R J Bott et al. What Type of Prostate Cancer Is Systematically Overlooked by Multiparametric Magnetic Resonance Imaging? An Analysis From the PROMIS Cohort. Eur Urol. 01 May 2020

 

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    2020-05-22 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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