Oncotarget：新型抗体药物偶联物ENDOS/ADC有持续抗骨肉瘤作用！

2017-08-10 Emma MedSci原创

ADC是一种新型靶向治疗药物，能够将抗体对靶标的选择性与细胞毒性药物的有效细胞杀伤活性相结合。Endosialin是由人类CD248基因编码的细胞表面蛋白，正常的成人组织endosialin表达较低甚至不表达，因此其成为靶向治疗的一个理想目标。

ADC是一种新型靶向治疗药物，能够将抗体对靶标的选择性与细胞毒性药物的有效细胞杀伤活性相结合。Endosialin是由人类CD248基因编码的细胞表面蛋白，正常的成人组织endosialin表达较低甚至不表达，因此其成为靶向治疗的一个理想目标。发表于Oncotarget的一篇文章中，研究人员基于hMP-E-8.3合成了针对endosialin的ADC，即一种新型抗体药物偶联物ENDOS/ADC，并调查了ENDOS/ADC在肿瘤中的作用。研究显示，细胞内表达水平较高的endosialin与有效的内化作用以及体外细胞毒性作用相关，在表达endosialin的肿瘤细胞系中，ENDOS/ADC显示强大的、特异性的和靶向依赖的杀伤活性。ENDOS/ADC治疗能够长期持续抑制人骨肉瘤细胞系模型的肿瘤生长。ENDOS/ADC有作为生物治疗剂开发的潜力，包括在骨肉瘤之外的endosialin阳性的其他恶性肿瘤中，可进行进一步的研究。原始出处：Capone E, et al. Generation of a novel Antibody-Drug Conjugate targeting endosial

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2018-04-30 12498e5fm12(暂无昵称)

#抗体药#

74 0
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2018-01-31 仁医06

#target#

60 0
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2018-06-22 zhanglin3079

#抗体药物#

61 0
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2017-08-12 chendoc243

#抗体药物偶联物#

81 0
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2017-08-11 1e10c84am36(暂无匿称)

文章很好，谢谢分享

90 0
[GetPortalCommentsPageByObjectIdResponse(id=1957608, encodeId=5780195e6087f, content=<a href='/topic/show?id=a09c551998a' target=_blank style='color:#2F92EE;'>#抗体药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55199, encryptionId=a09c551998a, topicName=抗体药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=793a2500200, createdName=12498e5fm12(暂无昵称), createdTime=Mon Apr 30 23:09:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795429, encodeId=6a941e95429d2, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Wed Jan 31 19:09:00 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2016161, encodeId=15fb20161616e, content=<a href='/topic/show?id=d0565520072' target=_blank style='color:#2F92EE;'>#抗体药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55200, encryptionId=d0565520072, topicName=抗体药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Fri Jun 22 03:09:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413820, encodeId=4e4e141382056, content=<a href='/topic/show?id=ce4a55202f0' target=_blank style='color:#2F92EE;'>#抗体药物偶联物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55202, encryptionId=ce4a55202f0, topicName=抗体药物偶联物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5ea3025344, createdName=chendoc243, createdTime=Sat Aug 12 07:09:00 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232298, encodeId=d0b4232298fa, content=文章很好，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Aug 11 01:20:25 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232202, encodeId=305c232202c3, content=ENDOS/ADC有作为生物治疗剂开发的潜力，包括在骨肉瘤之外的endosialin阳性的其他恶性肿瘤中，可进行进一步的研究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Thu Aug 10 17:03:09 CST 2017, time=2017-08-10, status=1, ipAttribution=)]
2017-08-10 有备才能无患

ENDOS/ADC有作为生物治疗剂开发的潜力，包括在骨肉瘤之外的endosialin阳性的其他恶性肿瘤中，可进行进一步的研究。

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Oncotarget：新型抗体药物偶联物ENDOS/ADC有持续抗骨肉瘤作用！

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