JCLA：塞来昔布治疗前后膝关节骨性关节炎患者miRNA表达谱的变化

2019-06-01 不详网络

本研究旨在研究塞来昔布治疗前后膝关节骨性关节炎(OA)患者循环miRNA表达谱的变化。

本研究旨在研究塞来昔布治疗前后膝关节骨性关节炎(OA)患者循环miRNA表达谱的变化。

本研究共招募接受塞来昔布治疗6周的218例膝关节OA患者。研究人员分别在基线(W0)和W6时采集血浆样本，用WOMAC指数评价治疗效果。探索阶段采用微阵列技术检测6例患者治疗前后血浆miRNA表达谱。随后，在验证阶段，通过qPCR对218例患者在微阵列治疗前后10个top差分表达mirna (DEMs)进行进一步验证。

研究发现，在探索阶段，通过PCA图和热图分析，可以将治疗后的患者与治疗前的患者区分开来，并通过火山图分别鉴定出45个上调和48个下调的mirna。在验证阶段，与W0相比，miR-126-5p和miR-320a的水平在W6时升高，而miR‐155‐5p和miR-146a-5p的水平下降。与W0相比，WOMAC疼痛/僵硬/生理功能评分在W6时均下降，71%的患者有临床反应。与非临床应答者相比，临床应答者miR-126-5p表达(W6‐W0)的增加要大得多。miRNA‐320a水平在非临床应答者中下降，而在临床应答者中上升。相反，miRNA-146a‐5p水平在非临床应答者中升高，而在临床应答者中降低。

循环miRNA表达谱在接受塞来昔治疗的膝关节OA患者中发挥重要作用，miR-126-5p、miR-320a以及miR-146a-5p可能与塞来昔治疗反应有关。

原始出处：

Zhao Dong, Honghui Jiang ,Change of miRNA expression profiles in patients with knee osteoarthritis before and after celecoxib treatment

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2022-08-27 循证小兵

膝关节#骨性关节炎#

104 0
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2019-12-12 小小小向日葵

#RNA表达#

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2019-06-17 smallant2002

#miR#

129 0
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2019-06-03 lmm397

#关节炎#

125 0
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2019-06-03 xiongke010

#塞来昔布#

105 0
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2019-06-03 Homburg

#miRNA#

124 0
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2019-06-03 changhe714

#膝关节骨性关节炎#

97 0

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JCLA：塞来昔布治疗前后膝关节骨性关节炎患者miRNA表达谱的变化

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