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JCB:周围神经损伤后修复新发现--Merlin蛋白周围神经损伤后修复新发现--Merlin蛋白

2017-07-12 zhuliee 来宝网

在细胞生物学杂志上发表的研究首次报道了人体的蛋白如何让外周神经系统(PNS)的神经在损伤后进行修复。



Merlin蛋白的发现揭示了周围神经损伤后修复的重要机制】在细胞生物学杂志上发表的研究首次报道了人体的蛋白如何让外周神经系统(PNS)的神经在损伤后进行修复。

该研究可以促进由于外伤或者战场损伤导致的神经损伤的患者进行有效的修复治疗

同样还希望能够治疗1型或者2型糖尿病导致的外周神经损伤。糖尿病患者忍受持续性的损伤,这也可以解释为什么他们的手脚频繁的烧伤和损伤。在大多数情况下,这种损伤是永久性的,目前几乎没有治疗的办法。

这一研究的关键是Merlin蛋白的发现,这种蛋白在抑制肿瘤的神经系统上起重要作用。该研究小组已经确定了Merlin蛋白缺乏时,如何导致大脑肿瘤和其他神经系统肿瘤的发生。在这项研究中第一次发现Merlin蛋白还在神经系统的修复过程中起重要作用。

该研究通过小鼠模型成功的发现Merlin蛋白在外周神经系统中的施万细胞上的新作用。施万细胞包裹并隔离携带脊髓及脑内信号的神经细胞突起。在损伤发生后,施万细胞具有独特的再生性能。而这项研究确定了Merlin蛋白在指导损伤后修复中起至关重要的作用。

在缺乏Merlin蛋白的施万细胞中,YAP蛋白的活化导致神经修复的失败。PNS损伤后修复调节通路的发现可能开启了治疗创伤后和年龄相关的外周神经系统损伤后修复提供新希望。

该研究由David Parkinson领导实施,他说:He said:“外周神经损伤的治疗方式有限,且对患者以后的生活具有很多不利的影响。我们非常兴奋,因为我们第一次发现了神经损伤后修复的机制。通过对机制的理解,我们可以研发从未有过的新的有效的治疗方法以促进神经修复。

原始出处:

Thomas Mindos,et al. Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity, Journal of Cell Biology, DOI: 10.1083/jcb.201606052.

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    2017-11-16 hmwwww
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  4. 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  5. 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    2017-07-18 海棠胜雪

    学习了

    0

  6. 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objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Jul 14 10:53:10 CST 2017, time=2017-07-14, status=1, ipAttribution=)]
    2017-07-17 医鸣惊人

    学习

    0

  7. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Mon Jul 17 09:39:49 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=223076, encodeId=789b2230e698, content=周围神经损伤后的修复。, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Mon Jul 17 07:25:43 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222851, encodeId=33ca222851b8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Jul 16 09:43:19 CST 2017, time=2017-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222532, encodeId=d373222532da, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Jul 15 10:36:36 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222194, encodeId=df1b22219449, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Jul 14 10:53:10 CST 2017, time=2017-07-14, status=1, ipAttribution=)]
    2017-07-17 jyzxjiangqin

    周围神经损伤后的修复。

    0

  8. 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objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Jul 14 10:53:10 CST 2017, time=2017-07-14, status=1, ipAttribution=)]
    2017-07-16 医鸣惊人

    学习

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Jul 14 10:53:10 CST 2017, time=2017-07-14, status=1, ipAttribution=)]
    2017-07-15 医鸣惊人

    学习

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Jul 16 09:43:19 CST 2017, time=2017-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222532, encodeId=d373222532da, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Jul 15 10:36:36 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222194, encodeId=df1b22219449, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Jul 14 10:53:10 CST 2017, time=2017-07-14, status=1, ipAttribution=)]
    2017-07-14 医鸣惊人

    学习

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