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NCOA4: More than a receptor for ferritinophagy

期刊: JOURNAL OF CELL BIOLOGY, 2022; 221 (10)

Liquid-liquid phase separation (LLPS) triages protein cargoes for autophagic degradation. In this issue, Ohshima et al. (2022. J. Cell Biol.) demonstr......

JIF:7.905

mTORC1 beyond anabolic metabolism: Regulation of cell death

期刊: JOURNAL OF CELL BIOLOGY, 2022; 221 (12)

Zhu et al. review the current knowledge on how mTORC1 activity is connected to cell death regulation through metabolic and signaling pathways. The mec......

JIF:7.905

Pluripotency exit is guided by the Peln1-mediated disruption of intrachromosomal architecture

期刊: JOURNAL OF CELL BIOLOGY, 2022; 221 (4)

Wang et al. identify Peln1 as a key chromatin lncRNA that controls the pluripotency exit in stem cells by trans regulating the Oct4 promoter and intra......

JIF:7.905

Cell migration orchestrates migrasome formation by shaping retraction fibers

期刊: JOURNAL OF CELL BIOLOGY, 2022; 221 (4)

Migrasomes are recently discovered vesicle-like structures on retraction fibers of migrating cells that have been linked with transfer of cellular con......

JIF:7.905

SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2(ZYG)(11)(B) activity

期刊: JOURNAL OF CELL BIOLOGY, 2022; 221 (7)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal pathogen of the ongoing global pandemic of coronavirus disease 2019 (COVID-......

JIF:7.905

CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1

期刊: JOURNAL OF CELL BIOLOGY, 2022; 221 (1)

The ESCRT protein CHMP2B and the RNA-binding protein TDP-43 are both associated with ALS and FTD. The pathogenicity of CHMP2B has mainly been consider......

JIF:7.905

Material properties of phase-separated TFEB condensates regulate the autophagy-lysosome pathway

期刊: JOURNAL OF CELL BIOLOGY, 2022; 221 (5)

Very little is known about how the material properties of protein condensates assembled via liquid-liquid phase separation (LLPS) are maintained and a......

JIF:7.905

IRSp53 promotes postsynaptic density formation and actin filament bundling

期刊: JOURNAL OF CELL BIOLOGY, 2022; 221 (8)

IRSp53 (aka BAIAP2) is a scaffold protein that couples membranes with the cytoskeleton in actin-filled protrusions such as filopodia and lamellipodia.......

JIF:7.905

DeepContact: High-throughput quantification of membrane contact sites based on electron microscopy imaging

期刊: JOURNAL OF CELL BIOLOGY, 2022; 221 (9)

Membrane contact site (MCS)-mediated organelle interactions play essential roles in the cell. Quantitative analysis of MCSs reveals vital clues for ce......

JIF:7.905

Pcp1/pericentrin controls the SPB number in fission yeast meiosis and ploidy homeostasis

期刊: JOURNAL OF CELL BIOLOGY, 2022; 221 (1)

During sexual reproduction, the zygote must inherit exactly one centrosome (spindle pole body [SPB] in yeasts) from the gametes, which then duplicates......

JIF:7.905

Lineage tracing clarifies the cellular origin of tissue-resident macrophages in the developing heart

期刊: JOURNAL OF CELL BIOLOGY, 2022; 221 (6)

Tissue-resident macrophages play essential functions in the maintenance of tissue homeostasis and repair. Recently, the endocardium has been reported ......

JIF:7.905

Filamin FLN-2 promotes MVB biogenesis by mediating vesicle docking on the actin cytoskeleton

期刊: JOURNAL OF CELL BIOLOGY, 2022; 221 (7)

Multivesicular bodies (MVBs) contain intralumenal vesicles that are delivered to lysosomes for degradation or released extracellularly for intercellul......

JIF:7.905

SNX5 targets a monoamine transporter to the TGN for assembly into dense core vesicles by AP-3

期刊: JOURNAL OF CELL BIOLOGY, 2022; 221 (5)

The time course of signaling by peptide hormones, neural peptides, and other neuromodulators depends on their storage inside dense core vesicles (DCVs......

JIF:7.905

Reconstitution and mechanistic dissection of the human microtubule branching machinery

期刊: JOURNAL OF CELL BIOLOGY, 2022; 221 (7)

Branching microtubule (MT) nucleation is mediated by the augmin complex and gamma-tubulin ring complex (gamma-TuRC). However, how these two complexes ......

JIF:7.905

LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole

期刊: JOURNAL OF CELL BIOLOGY, 2022; 221 (1)

Primary cilia transduce diverse signals in embryonic development and adult tissues. Defective ciliogenesis results in a series of human disorders coll......

JIF:7.905

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