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DCR:放大染色内镜在治疗结直肠肿瘤可疑粘膜下侵犯中的作用

2019-05-22 不详 MedSci原创

正确预测肿瘤浸润结直肠壁的深度对于内镜下切除浅表性结直肠肿瘤至关重要。本研究的目的是评估放大染色内镜检查的准确性,以预测具有黏膜下侵犯风险较高的结直肠肿瘤患者的入侵深度。

背景:
正确预测肿瘤浸润结直肠壁的深度对于内镜下切除浅表性结直肠肿瘤至关重要。本研究的目的是评估放大染色内镜检查的准确性,以预测具有黏膜下侵犯风险较高的结直肠肿瘤患者的入侵深度。

方法:
这是一项单中心回顾性研究,研究人员对2009年4月至2015年6月间具有高粘膜下侵犯风险的结肠直肠肿瘤的患者进行了回顾性分析。肿瘤的定义是大的(≥20mm)无柄息肉(非穿孔),横向扩散的肿瘤或任何大小的凹陷性病变。所有患者均接受放大染色内镜检查,并根据Kudo 凹坑模式进行分类。通过放大率评估来决定内窥镜或手术治疗。主要观察结局是确定放大染色内镜检查评估这些病变的敏感性,特异性和阳性和阴性预测值。

结果:
本项研究共纳入123个病灶,平均大小为54.0±37.1 mm。具有凹坑模式分类的术前放大染色内镜检查具有73.3%的敏感性,100%的特异性,100%的阳性预测值,96.4%的阴性预测值,以及96.7%的预测浸润深度的准确性。还通过MRI检查了33个直肠病变,31个被诊断为T2病变。

结论:
放大染色内镜检查对于评估可疑粘膜下浸润的结直肠肿瘤非常准确,可以帮助选择最合适的治疗方法。

原始出处:

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