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Oncogene:研究发现吸烟有关肺癌的生物标志物

2013-09-23 佚名 生物谷

近日,来自梅奥诊所的一项最新研究揭示,一种特定的蛋白质对可能成为识别吸烟有关肺癌的潜在预后标志物。 新研究发现,蛋白质ASCL1与RET原癌基因的表达增加有关。这一发现刊登在网上发行的Oncogene 杂志上。【原文阅读】 这是令人兴奋的,因为研究人员已经发现了“可成药的靶标”,梅奥诊所的分子医学研究员George Vasmatzis博士表示:ASCL1是侵略性

近日,来自梅奥诊所的一项最新研究揭示,一种特定的蛋白质对可能成为识别吸烟有关肺癌的潜在预后标志物。

新研究发现,蛋白质ASCL1与RET原癌基因的表达增加有关。这一发现刊登在网上发行的Oncogene 杂志上。【原文阅读】

这是令人兴奋的,因为研究人员已经发现了“可成药的靶标”,梅奥诊所的分子医学研究员George Vasmatzis博士表示:ASCL1是侵略性腺癌的一个明确标志物。

在吸烟者的肺中常常发现快速生长的癌细胞。ASCL1被认知能控制神经内分泌细胞的发育,以前认为还与调节甲状腺癌和小细胞肺癌的发展相关,但并未获知ASCL1与吸烟有关的肺癌相关。

这项研究还表明,携带ASCL1的肿瘤患者,一旦RET原癌基因蛋白处于高水平,生存期会明显缩短,而携带ASCL1患者在RET水平低的情况下,生存期相比较长。

当研究人员在肺癌细胞系中阻断ASCL1蛋白,RET水平的下降,肿瘤的生长减缓。这使得研究人员相信这种机制将是一个潜在的临床试验药品靶标。

原文阅读

Kosari F, Ida CM, Aubry MC, Yang L, Kovtun IV, Klein JL, Li Y, Erdogan S, Tomaszek SC, Murphy SJ, Bolette LC, Kolbert CP, Yang P, Wigle DA, Vasmatzis G.ASCL1 and RET expression defines a clinically relevant subgroup of lung adenocarcinoma characterized by neuroendocrine differentiation.Oncogene. 2013 Sep 16. 

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    2014-05-04 cy0324
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    2013-09-25 zsyan
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