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JACC:美国左心耳封堵注册数据库的近3年病例总结研究

2020-03-31 MedSci原创 MedSci原创

左心耳封堵(LAAO)预防心房颤动患者卒中的2项随机临床试验已经进行了评价,但是批准后的临床数据有限。本研究的目的是描述美国国家心血管数据注册中心(NCDR)LAAO注册中心(LAAO注册数据库)在其

左心耳封堵(LAAO)预防心房颤动患者卒中的2项随机临床试验已经进行了评价,但是批准后的临床数据有限。本研究的目的是描述美国国家心血管数据注册中心(NCDR)LAAO注册中心(LAAO注册数据库)在其最初3年中的患者、医院和医生特征以及Watchman手术操作的院内不良事件率。

本研究纳入分析了来自由美国495家医院的1318名医生进行了38158次手术,患者的平均年龄为76.1 ± 8.1岁,CHA2DS2-VASc平均评分为4.6 ± 1.5,HAS-BLED平均评分为3.0 ± 1.1,每家医院一年平均的LAAO手术量为30次。有7%的病例手术取消或者作废,在使用器械的病例中,98.1%的病例植入了小于5mm的封堵器。有2.16%患者发生了院内主要不良事件,最常见的并发症是需要干预的心包积液(1.39%)和大出血(1.25%),而中风(0.17%)和死亡(0.19%)是罕见的。

研究结果显示,LAAO注册数据库已纳入了超过38000名植入器械的房颤患者,患者通常比参与关键试验的患者年龄更大,合并症更多,但是,主要的院内不良事件发生率低于这些试验的报告。

原始出处:

James V et al.The NCDR Left Atrial Appendage Occlusion Registry.JACC.2020 Mar.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=901566, encodeId=9d409015661e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201123/916441d2913648269ede0b8db11ab6c2/0a36cd040f95424b9d105ae671387d9a.jpg, createdBy=52415437799, createdName=百度人生, createdTime=Mon Nov 23 20:45:06 CST 2020, time=2020-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1854716, encodeId=aec51854e1604, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Tue Jul 14 02:02:43 CST 2020, time=2020-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381302, encodeId=7bce381302e7, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Fri Apr 03 20:21:33 CST 2020, time=2020-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1326550, encodeId=0cdd132655036, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Apr 02 05:02:43 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1455619, encodeId=df321455619e3, content=<a href='/topic/show?id=d15a4808371' target=_blank style='color:#2F92EE;'>#左心耳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48083, encryptionId=d15a4808371, topicName=左心耳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Apr 02 05:02:43 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556893, encodeId=8c92155689397, content=<a href='/topic/show?id=e4016495635' target=_blank style='color:#2F92EE;'>#注册#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64956, encryptionId=e4016495635, topicName=注册)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c52c14833361, createdName=zhyy93, createdTime=Thu Apr 02 05:02:43 CST 2020, time=2020-04-02, status=1, ipAttribution=)]
    2020-11-23 百度人生

    学习

    0

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    2020-07-14 hbwxf
  3. [GetPortalCommentsPageByObjectIdResponse(id=901566, encodeId=9d409015661e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201123/916441d2913648269ede0b8db11ab6c2/0a36cd040f95424b9d105ae671387d9a.jpg, createdBy=52415437799, createdName=百度人生, createdTime=Mon Nov 23 20:45:06 CST 2020, time=2020-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1854716, encodeId=aec51854e1604, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Tue Jul 14 02:02:43 CST 2020, time=2020-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381302, encodeId=7bce381302e7, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Fri Apr 03 20:21:33 CST 2020, time=2020-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1326550, encodeId=0cdd132655036, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Apr 02 05:02:43 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1455619, encodeId=df321455619e3, content=<a href='/topic/show?id=d15a4808371' target=_blank style='color:#2F92EE;'>#左心耳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48083, encryptionId=d15a4808371, topicName=左心耳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Apr 02 05:02:43 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556893, encodeId=8c92155689397, content=<a href='/topic/show?id=e4016495635' target=_blank style='color:#2F92EE;'>#注册#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64956, encryptionId=e4016495635, topicName=注册)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c52c14833361, createdName=zhyy93, createdTime=Thu Apr 02 05:02:43 CST 2020, time=2020-04-02, status=1, ipAttribution=)]
    2020-04-03 wxl882001

    了解一下

    0

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    2020-04-02 zhyy93

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