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Hypertension:肾去交感神经术可降低卒中体积

2020-03-05 国际循环 国际循环

近期研究结果显示,肾去交感神经术(RDN)可用于治疗高血压,但RDN导致血压下降的确切机制尚不完全清楚。近日,Hypertension杂志发表研究对此进行分析。


近期研究结果显示,肾去交感神经术(RDN)可用于治疗高血压,但RDN导致血压下降的确切机制尚不完全清楚。近日,Hypertension杂志发表研究对此进行分析。
 
采用心脏磁共振成像技术评价RDN对高血压患者RDN治疗前后心功能的影响,并与假治疗对照。心脏磁共振成像用于评估主动脉流量测量中的卒中体积指数、心脏指数、心率、全身血管阻力指数和卒中功能指数。这项随机、RDN假对照试验中,难治性高血压患者在RDN前和随访时接受心脏磁共振成像(随机队列)。研究结果随后在接受RDN和心脏磁共振成像的难治性高血压患者队列(验证队列)中加以证实。
 
研究共纳入162例患者,其中110例被纳入随机试验(27例假治疗),52例纳入验证队列。在随机队列中,RDN队列中的卒中体积指数降低了(4.7±9.8) ml/m2,假治疗队列中没有变化(组间比较P=0.008)。RDN患者的心脏指数和卒中工作指数有降低的趋势,而假治疗组患者则没有显著变化[(-0.10±5.9) vs. (0.17±0.51) L/min/m2,(-7.1±12.5) vs. (-1.4±10.4) g/m2,两者的P=0.08)。与之相对,RDN后患者全身血管阻力指数和心率保持不变。在验证队列中,证实卒中体积指数的降低,心脏指数和卒中功指数也显著降低,而随访时全身血管阻力指数和心率保持不变。
 
在这项围绕难治性高血压患者展开的研究中,与假手术治疗相比,RDN显著减少卒中体积。
 
参考文献:
Philip Lurz, Karl-Patrik Kresoja, et al. Changes in Stroke Volume After Renal Denervation: Insight From Cardiac Magnetic Resonance Imaging. Hypertension. Originally published3 Feb 2020

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    2020-05-07 feather89
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  4. [GetPortalCommentsPageByObjectIdResponse(id=2039159, encodeId=3ca12039159e2, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Sun Mar 29 03:24:00 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728342, encodeId=0f421e2834280, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu May 07 00:24:00 CST 2020, time=2020-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501447, encodeId=5602150144e94, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sat Mar 07 10:24:00 CST 2020, time=2020-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026587, encodeId=af90102658e6d, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Mar 05 22:24:00 CST 2020, time=2020-03-05, status=1, ipAttribution=)]
    2020-03-05 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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