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JAHA:无症状性心肌梗死与心脏猝死长期风险之间的关系

2020-12-30 MedSci原创 MedSci原创

一般人群SMI与SCD风险增加有关

尽管无症状性心肌梗塞(SMI)在预后上很重要,但SMI患者发生猝死(SCD)的风险尚未明确。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员评估了2个基于社区的队列:社区动脉粥样硬化风险(ARIC)研究( n=13725)和心血管健康(CHS)研究(n=5207)。SMI被定义为基线时尚不存在但在随访期间新发的心肌梗死心电图证据。该研究的主要终点为医师确诊的SCD。

在ARIC研究中,25.4年的中位随访期间,发生了513例SMI,441例心肌梗塞(CMI)和527例SCD事件。SMI和CMI患者发生SCD的多变量风险比分别为5.20(95%CI为3.81-7.10)和3.80(95%CI为2.76-5.23)。在CHS中,中位随访时间为12.1年,发生了1070例SMI,632例CMI和526例SCD事件。SMI和CMI患者发生SCD的多变量风险比分别为1.70(95%CI为1.32-2.19)和4.08(95%CI为3.29-5.06)。SMI和CMI患者发生SCD的综合风险比分别为2.65(2.18–3.23)和3.99(3.34–4.77)。白人、男性和年龄较小与SMI相关的SCD风险更高。SMI患者SCD人群归因于比为11.1%,SMI与每1000人每年8.9例SCD的绝对风险增加相关。添加SMI可显著提高了对SCD和非SCD的预测效能。

由此可见,一般人群SMI与SCD风险增加有关

原始出处:

Yun‐Jiu Cheng.et al.Association Between Silent Myocardial Infarction and Long‐Term Risk of Sudden Cardiac Death.J AM HEART ASSOC.2020.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.017044

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    2020-12-31 zhaohui6731
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    2020-12-30 神盾医疗局局长Jack

    一般人群SMI与SCD风险增加有关

    0

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    2020-12-30 ms9000001535796802

    学习了!

    0

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