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Hepatology:调控肝脏脂肪化新基因Nogo-B被发现

2016-12-22 健康报 健康报

安徽省合肥工业大学科研团队最近发现的调控肝脏脂肪化基因有助于认识非酒精性脂肪肝的发病机理,有望为非酒精性脂肪肝的治疗提供新的药物靶点。该成果刊登在肝脏研究领域国际期刊《肝脏学》上。<div><br>非酒精性脂肪肝是指与饮酒、肝炎病毒等无关的因素所引起的肝脏中甘油三酯与脂肪酸的过度堆积,在我国普通人群中发病率超过20%。其发病率在肥胖、<a class="channel_keylink" href="//m.capotfarm.com/article/list.do?q=%E7%B3%96%E5%B0%BF%E7%97%85">糖尿病</a>等胰岛素抵抗人群中更是高达75%,且可由单纯性肝脏脂肪变性与脂肪性肝炎发展到肝纤维化和硬化,甚至肝癌,严重威胁国人的健康。目前,临床上认为,肥胖、<a class="channel_keylink" href="//m.capotfarm.com/article/list.do?q=%E7%B3%96%E5%B0%BF%E7%97%85">糖尿病</a>、长期使用激素、不当的饮食与生活方式以及锻炼不足等均是其致病原因,但对其发病具体机制仍

安徽省合肥工业大学科研团队最近发现的调控肝脏脂肪化基因有助于认识非酒精性脂肪肝的发病机理,有望为非酒精性脂肪肝的治疗提供新的药物靶点。该成果刊登在肝脏研究领域国际期刊《肝脏学》上。


非酒精性脂肪肝是指与饮酒、肝炎病毒等无关的因素所引起的肝脏中甘油三酯与脂肪酸的过度堆积,在我国普通人群中发病率超过20%。其发病率在肥胖、糖尿病等胰岛素抵抗人群中更是高达75%,且可由单纯性肝脏脂肪变性与脂肪性肝炎发展到肝纤维化和硬化,甚至肝癌,严重威胁国人的健康。目前,临床上认为,肥胖、糖尿病、长期使用激素、不当的饮食与生活方式以及锻炼不足等均是其致病原因,但对其发病具体机制仍缺乏了解,对应的治疗手段非常有限。

合肥工业大学***特聘教授韩际宏课题组,与美国威斯康辛医学院合作开展的研究,发现了新的调控肝脏脂肪化的基因Nogo-B蛋白受体。Nogo-B蛋白受体又称NgBR。该项研究发现,肝脏中NgBR蛋白水平降低与脂肪肝发病有直接关系。在相关实验中,敲除NgBR基因的小鼠肝脏中积累了大量甘油三酯与自由脂肪酸。研究证实,这种脂肪的积累是由于NgBR水平下降导致调控肝脏脂肪酸合成的中枢分子肝X受体alpha的核转移与激活,同时与具有增强体内能量代谢传感器功能的腺苷酸活化蛋白激酶alpha失活密切相关。

原始出处:

Hu W, Zhang W, Chen Y, Rana U, Teng RJ, Duan Y, Liu Z, Zhao B, Foeckler J, Weiler H, Kallinger RE, Thomas MJ, Zhang K, Han J, Miao QR. Nogo-B receptor deficiency increases liver X receptor alpha nuclear translocation and hepatic lipogenesis through an adenosine monophosphate-activated protein kinase alpha-dependent pathway. Hepatology. 2016 Nov;64(5):1559-1576

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    2017-03-16 1e0f43f9m65(暂无匿称)

    学习了

    0

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    2016-12-24 gwc384
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    2016-12-22 雾夜芭蕾

    这一研究好多比较有用的

    0

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近日,合肥工业大学科研团队在细胞与分子水平上取得一项研究成果,探明了非酒精性脂肪肝发病机理,发现了新的调控肝脏脂肪化基因。该成果刊登在《肝脏学》上。

非酒精性脂肪肝病因复杂,对应的治疗手段非常有限。合肥工业大学***特聘教授韩际宏课题组,与美国威斯康辛医学院开展合作研究,发现了新的调控肝脏脂肪化的基因Nogo-B蛋白受体,有望为非酒精性脂肪肝的治疗提供新的药物靶点。

Nogo-B蛋白受体又称NgBR。该项研究发现,肝脏中NgBR蛋白水平降低与脂肪肝发病有直接关系。在相关实验中,敲除NgBR基因的小鼠肝脏中积累了大量甘油三酯与自由脂肪酸。研究证实,这种脂肪的积累是由于NgBR水平下降导致调控肝脏脂肪酸合成的中枢分子肝X受体alpha的核转移与激活,同时与具有增强体内能量代谢传感器功能的腺苷酸活化蛋白激酶alpha失活密切相关。

据介绍,目前临床上用于降 · 2016-12-20

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清华长庚直播肝脏“虫癌”手术 百万观众正能量爆棚

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医生们掐指一算,这是国庆长假要到来的节奏。根据往年的经验,节日期间醉酒人数肯定还会持续增加。这也是可以理解,过节么,图的就是一个气氛。亲朋好友相聚一堂,桌上觥筹交错,推杯换盏,兴致一起,忘乎所以,稍不留神,烂醉如泥。饮酒在中国是一种礼仪,完全的杜绝饮酒还为时尚早,因此如何才能最大限度的减少酒精对健康的伤害,且听听医生怎么说。酒精对人体的伤害急诊科副主任张蓉认为,酒精对人体的损害,最重要的是中枢神经

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