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JCI：帕金森氏症细胞替代疗法的新突破

2014-08-25 佚名 生物谷

帕金森氏症细胞替代疗法神经元
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2014年8月25日讯 /生物谷BIOON/--帕金森氏症影响全球数百万人，起因于神经元的损失。研究发现移植胎儿组织在恢复神经元的损失中显露出“才华”，但该组织的来源和使用伦理问题限制其运用。 在杂志Journal of Clinical Investigation研究中，圣拉斐尔科学研究所Vania Broccoli等人成功将成纤维细胞转化为神经元，并“嫁接”到帕金森病啮齿动物的大脑中

2014年8月25日讯 /生物谷BIOON/--帕金森氏症影响全球数百万人，起因于神经元的损失。研究发现移植胎儿组织在恢复神经元的损失中显露出“才华”，但该组织的来源和使用伦理问题限制其运用。

在杂志Journal of Clinical Investigation研究中，圣拉斐尔科学研究所Vania Broccoli等人成功将成纤维细胞转化为神经元，并“嫁接”到帕金森病啮齿动物的大脑中。

这些神经元细胞改善运动功能，但功效不及移植大鼠胎儿组织。然后，研究人员使用一种技术，让神经元表达工程蛋白（这些蛋白能调节神经元的活动）。结果发现这些神经元恢复运动功能的功效几乎与移植胚胎组织一样。

新研究提示：成纤维细胞或可用于帕金森氏症的细胞替代疗法。

原始出处：

Dell'Anno MT, Caiazzo M, Leo D, Dvoretskova E, Medrihan L, Colasante G, Giannelli S, Theka I, Russo G, Mus L, Pezzoli G, Gainetdinov RR, Benfenati F, Taverna S, Dityatev A, Broccoli V.Remote control of induced dopaminergic neurons in parkinsonian rats.J Clin Invest. 2014 Jul 1;124(7):3215-29. doi: 10.1172/JCI74664.[pdf free]

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    2014-10-09 caobinglei8079

    #JCI#

    0

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    2015-07-21 skhzy

    #替代疗法#

    0

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    2014-12-23 zxxiang

    #新突破#

    0

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    2015-07-02 ms6832696159214430

    #细胞替代疗法#

    0

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    2014-08-26 rosa00tong

    干细胞的确可能使退化的细胞重现生机

    0

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日前，日本研究人员日前在英国《自然》杂志网络版上报告说，人体在清除会导致帕金森氏症的异常线粒体时，会出现一种特殊的蛋白质。如果医生能在检查时发现这种蛋白质增加，就有可能尽早诊断帕金森氏症。 帕金森氏症是一种中老年人常见的中枢神经系统变性疾病，主要表现为手脚震颤和身体僵硬等，并发认知障碍的概率很高。遗传性帕金森氏症是由于 Pink1 和帕金两种基因无法发挥作用，导致细胞内的异常线粒体蓄积，最终使神经

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