Am J Transl Res：研究揭示当归补血汤治疗糖尿病肾病的机制

2017-09-06 MedSci MedSci原创

当归补血汤（DBT）是一种中医汤剂，研究已经证实其可有效治疗糖尿病肾病（DN）。在这项研究中，研究人员探讨了DBT在DN治疗中的潜在机制。研究人员通过DBT为小鼠灌胃制备含血清的DBT。用ELISA检测细胞培养液中的纤维连接蛋白(FN)、层粘连蛋白（LN）、Ⅳ型胶原（COL IV）和TGF-β1蛋白的水平。采用qRT-PCR和Western blotting测定相关分子的mRNA及蛋白的表达。MT

当归补血汤（DBT）是一种中医汤剂，研究已经证实其可有效治疗糖尿病肾病（DN）。在这项研究中，研究人员探讨了DBT在DN治疗中的潜在机制。

研究人员通过DBT为小鼠灌胃制备含血清的DBT。用ELISA检测细胞培养液中的纤维连接蛋白(FN)、层粘连蛋白（LN）、Ⅳ型胶原（COL IV）和TGF-β1蛋白的水平。采用qRT-PCR和Western blotting测定相关分子的mRNA及蛋白的表达。MTT法检测细胞增殖。

结果显示，DBT对高糖（HG）诱导的细胞增殖和肾小球系膜细胞（MC）累积的细胞外基质（ECM）产生负面影响。进一步的研究表明，DBT可减少PVT1启动子位点组蛋白H3的乙酰化水平以促进PVT1下调，同时伴随着TGF-β和c-myc的表达减少。此外，PVT1过表达可显著增强细胞活力，并促进TGF-β1基因的表达水平。此外，PVT1过表达可显著逆转DBT抑制高糖诱导的细胞活力和细胞外基质积聚，同时还可去除DBT对TGF-β1和c-myc表达的影响。

总之，该研究结果表明，通过下调PVT1，DBT可抑制TGF-β1和c-myc的表达，从而减弱MCS的过度增殖和ECM的累积。

原始出处：

Rui Zhang, Jinbo Li, Tao Huang, Xiuge Wang. Danggui buxue tang suppresses high glucose-induced proliferation and extracellular matrix accumulation of mesangial cells via inhibiting lncRNA PVT1. Am J Transl Res. 2017; 9(8): 3732–3740. Published online 2017 Aug 15.

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2017-09-07 ms3025846204744509

#Transl#

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2017-09-20 bsmagic9140

#TRA#

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2017-09-07 doctorJiangchao

继续学习.

122 0
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2017-09-07 天涯183

非常好的文章.学习了

118 0
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2017-09-07 189****7206

学习了受益匪浅

163 0
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2017-09-06 QFXL123456

学习了.谢谢!

110 0
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2017-09-06 楠博One

中药中医博大精深

153 0

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