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Science:建立人类微生物组化学库的宏基因组学策略

2019-10-20 海北 MedSci原创

最近几年,研究人员已经在确定微生物组对人类生理和疾病的影响方面取得了显着进展,但是控制这些作用的潜在分子和机制在很大程度上尚待探索。

最近几年,研究人员已经在确定微生物组对人类生理和疾病的影响方面取得了显着进展,但是控制这些作用的潜在分子和机制在很大程度上尚待探索。

最近,研究人员将新的计算算法与合成生物学相结合,以直接在人类微生物组宏基因组测序数据中挖掘编码具有生物活性的小分子。

研究人员发现,临床使用的一类分子的成员在人类微生物组中得到广泛编码,并且它们对邻近的微生物发挥有效的抗菌活性,这暗示着其在微环境竞争和宿主防御中可能发挥的作用。

该方法为系统揭示人类微生物组编码的化学成分铺平了道路,并为发现微生物组与宿主,以及微生物组与微生物组相互作用的分子介质提供了可推广的平台。


原始出处:

Yuki Sugimoto et al. A metagenomic strategy for harnessing the chemical repertoire of the human microbiomeScience, 2019; DOI: 10.1126/science.aax9176


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    2019-10-22 jichang
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