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Stroke:无房颤的肥厚型心肌病发生栓塞的危险因素——高龄、左心房扩大

2016-05-31 phylis 译 MedSci原创

背景:卒中和全身性栓塞事件是肥厚性心肌病(HCM)的并发症,这些并发症在伴有心房颤动(AF)患者中更常见。但是,房颤的诊断有时是很困难的,它可能是亚临床无症状的阵发性发作或首次发作的房颤,都可能导致栓塞事件。研究者调查HCM患者栓塞事件的发生率,并且评估无房颤记录患者发生卒中或全身性栓塞的危险因素。方法:该研究纳入了1980到2010年,593例临床诊断为HCM的患者(诊断时的年龄,51±15.6

背景:卒中和全身性栓塞事件是肥厚型心肌病(HCM)的并发症,这些并发症在伴有房颤(AF)患者中更常见。但是,房颤的诊断有时是很困难的,它可能是亚临床无症状的阵发性发作或首次发作的房颤,都可能导致栓塞事件。研究者调查HCM患者栓塞事件的发生率,并且评估无房颤记录患者发生卒中或全身性栓塞的危险因素。

方法:该研究纳入了1980到2010年,593例临床诊断为HCM的患者(诊断时的年龄,51±15.6岁)。

结果:平均随访时间为10.7±7.5年,68(11.5%)例发生了卒中和栓塞事件。事件发生前,29(42.6%)患者已发生AF。在发生卒中和栓塞事件时,5例(7.4%)是首次记录发生房颤,10例(14.7%)是事件发生后记录发生房颤。在无房颤记录的431患者中(39例发生事件和392未发生事件),校正性别和与HCM相关的典型的预测标志物后,诊断时高龄、左心房内径≥48mm是栓塞事件的独立危险因素。

结论:HCM患者脑卒中和栓塞事件的发生率为每年1%,栓塞事件发生前,一半以上的患者无房颤记录。高龄和左心房扩大是无记录房颤患者发生血栓事件可能的危险因素。

原始出处:

Haruki S, Minami Y, Hagiwara N. Stroke and Embolic Events in Hypertrophic Cardiomyopathy: Risk Stratification in Patients Without Atrial Fibrillation. Stroke. 2016 Apr.


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    2017-04-11 ylz8411
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    2016-06-02 xlysu
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    2016-06-02 sodoo

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Stroke:无房颤记录的肥厚型心肌病患者发生栓塞的危险因素是什么?

卒中和全身栓塞事件是肥厚型心肌病(HCM)的并发症,这些并发症在伴随心房颤动(AF)的患者中更常见。AF的诊断有时是困难的,但是,它有可能是亚临床无症状的阵发性发作或者是之前没有房颤记录的患者首次AF发作可能导致的栓塞事件。研究人员调查了HCM患者栓塞事件的发生率,并评估了没有记录AF的患者发生这些事件的风险因素。该研究纳入了从1980年至2010年的593例临床诊断为HCM的患者(诊断时年龄,5

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