SCI REP：卵巢癌患者辅助化疗起始时间与生存率之间的关系！

2017-08-25 xing.T MedSci原创

总之，辅助化疗起始时间延长与卵巢癌患者总体生存率降低有关，尤其是在晚期卵巢癌患者。

虽然一些研究已经调查了辅助化疗开始的时间与卵巢癌生存率之间存在相关性，但是不同研究对这个问题的结果并不一致。近日，Scientific reports 杂志上针对这一问题发表了一篇荟萃分析文章。

研究人员检索了PubMed、Web of Science等数据库，检索时间截止至2017年5月24日，研究人员检索了调查上述问题的队列研究。其中，十四项研究包含59569例卵巢癌患者被纳入在这项荟萃分析。研究人员对开始辅助化疗的最长和最短时间以及剂量-反应分析进行了荟萃分析，以评估总风险比率（HRs）和95%可信区间（CIs）。应用随机效应模型被用于估计HR与95%CI。

当将最长和最短辅助化疗时间进行比较，对于整体存活率总的HR为1.18（95%CI为1.06-1.32；I2=17.6；n=7）。此外，每延迟一周可以观察到总生存期存在显著的剂量-反应关系（HR为1.04；95%CI为1.0-1.09；I2=9.05；n=5）。值得注意的是，在前瞻性队列研究以及晚期（FIGOⅢ-Ⅳ期）患者的研究中，这些研究结果较为明显。研究人员没有观察到发表偏倚的证据。

总之，辅助化疗起始时间延长与卵巢癌患者总体生存率降低有关，尤其是在晚期卵巢癌患者。

原始出处：

Yi Liu,et al. Relationship between initiation time of adjuvant chemotherapy and survival in ovarian cancer patients: a dose-response meta-analysis of cohort studies.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-10197-1

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2017-08-28 大爰

学习了谢谢分享!!

70 0
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2017-08-27 guoyibin

#生存率#

64 0
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2017-08-26 luominglian113

学习了.谢谢分享

64 0
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2017-08-26 天涯183

非常好的文章.学习了.很受益

95 0
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2017-08-26 189****7206

学习了谢谢分享

81 0
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2017-08-25 changjiu

学习了.谢谢

74 0
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2017-08-25 189****7206

学习了谢谢分享

73 0

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