DIABETOLOGIA：老年人2型糖尿病，脑萎缩和认知能力下降

2019-04-03 不详网络

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该研究的目的是检查2型糖尿病是否与更大的脑萎缩和认知能力下降相关，以及脑萎缩是否介导2型糖尿病与认知能力下降之间的关联因素。

老年塔斯马尼亚人(CDOT)研究中，55岁至90岁无痴呆和糖尿病的参与者在4.6年的时间点上接受了三个时间点的脑MRI(心室和大脑总容量)和神经心理学测量(全球功能和七个认知域)。研究人员利用混合模型研究2型糖尿病与认知和MRI测量的纵向关联，并根据协变量进行调整。采用一项调解测试确定大脑萎缩是否解释了2型糖尿病和认知能力下降之间的关系。

结果显示，在基线时共有705名参与者（糖尿病：n = 348，平均年龄68.2岁[SD 7.0];无糖尿病：n = 357，平均年龄72.5岁[SD 7.1]）。校正年龄，性别，教育程度和血管危险因素，有明显的糖尿病×时间相互作用的言语记忆（β-0.06; 95％CI -0.09，-0.02）和言语流畅性（β-0.03; 95％CI -0.06， -0.00）。虽然糖尿病患者的基线时脑容量较低（β-14.273; 95％CI -21.197，-6.580），心室容量较大（β2.672; 95％CI 0.152,5.193），但没有明显的糖尿病×时间相互作用（p > 0.05）或通过脑萎缩介导糖尿病认知关系的证据。

在年龄较大的社区居民中，2型糖尿病与约5年的言语记忆和流畅性下降有关。糖尿病对脑萎缩的影响可能更早（中年）开始。

原始出处：

Michele L. Callisaya, Richard Beare, Type 2 diabetes mellitus, brain atrophy and cognitive decline in older people: a longitudinal study

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2019-09-14 chendoc252

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2019-06-24 ms5439512287675881

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2019-04-05 smartjoy

#脑萎缩#

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2019-04-05 hukaixun

#认知能力下降#

73 0
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2019-04-03 misszhang

谢谢MedSci提供最新的资讯

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