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Hypertension:妊娠期高血压并发症与静脉血栓栓塞风险

2020-01-14 xing.T MedSci原创

总之,妊娠期高血压和先兆子痫与妊娠期和产后期以及之后的13年中VTE风险增加相关。

妊娠期高血压和先兆子痫与后续动脉血栓形成风险增加有关。这些并发症是否与妊娠短期和长期(即妊娠之后)的静脉血栓栓塞(VTE)风险之间存在相关性目前尚不清楚。近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员通过将荷兰围产期登记处(Perined)与抗凝诊所联系起来,对至少妊娠1次且具有VTE风险的妇女进行了一项全国性队列研究。

研究人员使用Cox比例风险模型估算了妊娠期高血压妇女、先兆子痫妇女与正常妊娠妇女相比发生VTE的风险比(HRs)和相应的95%CI。

该研究共有1919918名妇女接受随访,随访时间中位数为13.7年(四分位间距为7.6-19.2),共随访24531118人次每年,其中5759例受试者首次发生VTE。发病率为:每10000人每年2.3人(95%CI为2.3–2.4)。在第一胎和产后3个月,相比于正常孕妇,高血压妇女VTE风险的HR较高,为2.0(95%CI为1.7-2.4),子痫前期妇女的VTE风险最高,HR为7.8,95%CI为5.4-11.3。从长期来看,妊娠和子痫前期高血压妇女的VTE风险较高:相对于对照组,HR为1.5(95%CI为1.4-1.6)和HR为2.1(95%CI为1.8-2.4)。如果排除妊娠和产后事件,则这些HR分别为1.4(95%CI为1.3-1.5)和1.6(95%CI为1.4-2.0)。

总之,妊娠期高血压和先兆子痫与妊娠期和产后期以及之后的13年中VTE风险增加相关。

原始出处:

Luuk J.J. Scheres.et al.Hypertensive Complications of Pregnancy and Risk of Venous Thromboembolism.Hypertension.2020.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.14280

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    2020-08-20 丁鹏鹏
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    2020-06-09 一叶知秋
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    2020-10-15 fusion
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