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J Biol Chem:绿茶能降低心脏病风险?

2018-06-10 佚名 中国生物技术网

近日,科学家们在绿茶中发现的一种物质有望开发出新方法来降低心脏病发作的风险。但是专家们称,这并不意味着我们应该赶紧去沏一壶绿茶了。

近日,科学家们在绿茶中发现的一种物质有望开发出新方法来降低心脏病发作的风险。但是专家们称,这并不意味着我们应该赶紧去沏一壶绿茶了。

这项近日发表在《Journal of Biological and Chemistry》上的研究发现,绿茶中的表没食子儿茶素(EGCG)分子能与一种存在于与冠状动脉疾病相关斑块中的蛋白质结合,在某些情况下,能使斑块变得更易溶解。

尽管科学家们称,这项最新发现为开发出解决导致冠状动脉疾病的血管内沉积物的分子带来了新的可能性,但是现在说绿茶能够帮助治疗这种疾病还为时过早。

英国兰卡斯特大学的David Middleton教授是研究人员之一,他说:“如果你只喝正常剂量的绿茶,那么它可能不会有效果。我们需要更仔细地分析这种分子,弄清楚怎么样对它进行调整才能使它更容易被身体吸收,或者直接递送到斑块的位置。”

在过去的研究中发现,EGCG能够影响某些蛋白质的结构,而这些蛋白质正是形成了与阿尔兹海默症相关的斑块。

这项研究由利兹大学和兰卡斯特大学的研究人员完成。他们撰文描述了探究绿茶对apoA-I蛋白质作用的过程:这种蛋白质是所谓的“有益胆固醇”HDL的关键组成部分,但是它也有负面作用。

Middleton说:“这种蛋白质本身会在体内有一定量的存在,而且随着我们年龄的增长尤其如此。”他补充说,在某些情况下,这些蛋白质会发生错误折叠并形成细小纤维,这些纤维会积聚在动脉的斑块中。有研究认为,这些纤维会使斑块更容易分解成大块,从而增加心脏病和中风的风险。

在这项研究中,研究人员选择用微波炉泡制绿茶,这对于品茶专家来说可能不是个好主意。在经过了仔细的分析之后,他们发现绿茶中的EGCG能与这种蛋白质中的纤维结合。

此外,EGCG似乎将这些蛋白质中的细小纤维分解为更细小的圆形的可溶形式,类似细胞间的物质。

有些专家给出了谨慎的意见,他们指出,均衡饮食、不吸烟和保持健康生活方式是个体降低冠状动脉疾病的关键。

格拉斯哥大学的Naveed Sattar教授说:“最近的这项研究还处于非常初期,我们过去曾经发现食物或饮品中存在某些降低健康风险的物质,但是迄今为止,这些物质很少带来真正的进步。所以,我的建议是,大家先别急着喝绿茶。”

James Brown博士是英国阿斯顿大学生物和生物医学高级讲师,他也谨慎地指出,喝绿茶和发现绿茶中的物质对身体有益并不是一回事。

他补充说,人体会分解绿茶中的成分,但目前尚不清楚EGCG最终在血液中是什么形式。这项研究还没有对体内存在这种斑块的小鼠或人类进行研究——让他们喝绿茶或EGCG,然后发现斑块是否减少。

原始出处:David Townsend , Eleri Hughes , Geoffrey Akien , et al. Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin. Journal of Biological Chemistry , 2018

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    2019-04-01 sunylz
  2. 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    2018-06-25 tjdsyyzg

    从目前证据看.饮茶无害可能预防冠心病和癌症.

    0

  4. 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likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sun Jun 10 08:39:56 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322983, encodeId=a03c32298365, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Jun 10 08:00:23 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322965, encodeId=5f6b32296514, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jun 10 07:25:57 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-15 衣带渐宽

    学习

    0

  5. 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time=2018-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402355, encodeId=b61a14023552e, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Mon Jun 11 15:07:00 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559723, encodeId=641d1559e23b0, content=<a href='/topic/show?id=b8435162302' target=_blank style='color:#2F92EE;'>#心脏病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, 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likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sun Jun 10 08:39:56 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322983, encodeId=a03c32298365, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Jun 10 08:00:23 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322965, encodeId=5f6b32296514, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jun 10 07:25:57 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-11 hbwxf
  6. 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  7. 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  8. 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time=2018-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402355, encodeId=b61a14023552e, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Mon Jun 11 15:07:00 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559723, encodeId=641d1559e23b0, content=<a href='/topic/show?id=b8435162302' target=_blank style='color:#2F92EE;'>#心脏病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, 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likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sun Jun 10 08:39:56 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322983, encodeId=a03c32298365, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Jun 10 08:00:23 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322965, encodeId=5f6b32296514, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jun 10 07:25:57 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-10 医者仁心5538

    继续努力

    0

  9. 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likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sun Jun 10 08:39:56 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322983, encodeId=a03c32298365, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Jun 10 08:00:23 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322965, encodeId=5f6b32296514, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jun 10 07:25:57 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-10 明月清辉

    谢谢分享.学习了

    0

  10. 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likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sun Jun 10 08:39:56 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322983, encodeId=a03c32298365, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Jun 10 08:00:23 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322965, encodeId=5f6b32296514, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jun 10 07:25:57 CST 2018, time=2018-06-10, status=1, ipAttribution=)]
    2018-06-10 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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