MedSci 专访天士力苏晶：芪参益气滴丸治疗中国心衰患者多中心研究启动

2015-10-22 MedSci MedSci原创

MedSci：苏总，您好！感谢您接受我们的采访。据了解，由天士力研发生产的芪参益气滴丸适应证包括冠心病、心绞痛等病症。目前天士力正在着手开展芪参益气滴丸治疗中国心衰患者的多中心临床研究，请您简要介绍一下芪参益气滴丸对中国心衰患者存在潜在获益的临床证据或理论根据。苏晶：由天士力研究院和天津中医药大学张伯礼院士团队联合研发的芪参益气滴丸，与天士力复方丹参滴丸在成份上是不同的。芪参益气滴丸的成份主要

MedSci：苏总，您好！感谢您接受我们的采访。据了解，由天士力研发生产的芪参益气滴丸适应证包括冠心病、心绞痛等病症。目前天士力正在着手开展芪参益气滴丸治疗中国心衰患者的多中心临床研究，请您简要介绍一下芪参益气滴丸对中国心衰患者存在潜在获益的临床证据或理论根据。

苏晶：由天士力研究院和天津中医药大学张伯礼院士团队联合研发的芪参益气滴丸，与天士力复方丹参滴丸在成份上是不同的。芪参益气滴丸的成份主要为：黄芪、丹参、三七、降香油。从中医药角度来讲，黄芪的主要作用是提高患者免疫力、增强心肌能量代谢和改善心肌供血。芪参益气滴丸适应证包括冠心病，但在实际临床应用中我们发现，很多在中医上表现为气虚气短的患者，在服用芪参益气滴丸后，上述症状改善比较明显，包括部分检测指标也有很大改善。

众所周知，心力衰竭是心血管疾病的终末期表现。天士力与张健教授及其他在心衰领域比较知名的专家交流过，目前在心功能不全领域的治疗药物还比较有限，特别是西药，近几年在治疗心功能不全方面也鲜有突破性进展。但随着人口老龄化不断加剧和冠心病前期治疗手段的不断改进，患者的存活时间会越来越长，而最终可能会引发或出现心功能不全，所以心功能不全患者数量也会不断增加。因此，基于这样一个背景，天士力开始从中医、中药的角度不断积极探索，希望能从中药的角度为心功能不全患者提供一种更好的治疗手段或者治疗选择，特别是在与西药联合方案方面。因为这类患者病程往往都比较长，病情比较复杂，可能很多脏器都会受到不同程度的牵连和损伤。所以从中医中药的角度来讲，天士力也非常希望与心血管领域的专家们积极开展这方面的探索，这也是天士力开展此项研究的目的。

MedSci：请您简单介绍一下“芪参益气滴丸治疗中国心力衰竭患者多中心随机、双盲、安慰剂对照临床研究”的开展情况？

苏晶：目前这项研究刚刚启动，研究方案已经与张健教授进行了多次完善，基本确定并且得到了包括高润霖院士、黄俊教授等国内心衰领域知名专家的认可。作为天士力目前为止开展的最大规模样本量研究，待该研究方案最终确定后，天士力将与国内多家地区的医院临床研究基地及中心进行沟通。今天通过研究启动发布会的形式，天士力邀请众多研究参与专家进行讨论，以期更好地推动这项研究的顺利进行。

MedSci：众所周知，中药作为中国独有的传统文化，与西药相比在药理方面存在很大差异。请您简单谈谈芪参益气滴丸与治疗心衰的西药相比在药理方面的差异。

苏晶：西药往往为单一靶点治疗，药物成份明确清晰的作用在某一个靶点上，例如ACEI仅仅是作用于抑制血管紧张素转化酶单一靶点上。而对于中药来说，因为属于组份中药。以芪参益气滴丸为例，该药由四味药组成，所以说它是一个多靶点的治疗效果，目前主要体现在改善冠状动脉的供血，提高心肌细胞的耐氧，改善心肌细胞的能量代谢等方面。因此，芪参益气滴丸起到的是一个多靶点的保护作用，能进一步改善患者整体心脏功能，而不是仅就解决一个单一靶点的问题，这也是天士力对中药比较看好的一个原因。

MedSci：请您结合目前中西药在治疗心衰方面的总体情况，展望一下芪参益气滴丸在治疗心衰方面的未来市场前景？

苏晶：天士力对芪参益气滴丸心衰治疗前景非常有信心。如前所述，一方面心衰患者数量会日益增多，另一方面，目前心衰有效治疗方法不多，至少从目前来讲突破性的西药还没有出现。而对于中药，国内有一些药物可能已经尝试开始在做这方面的研究了。而对于天士力来说，作为我国中药现代化的领先企业，紧紧围绕“以中药现代化为核心，集药材种植、药物研发、中间提取、药品制造、市场营销及售后服务于一体”的现代中药产业链建设，获得了包括“最具持续创新力的公司”称号在内的多项国家级荣誉，我们希望从中医中药的角度研发出创新药物，也希望芪参益气滴丸在治疗心衰方面能有突破性的创新和发展。既往，天士力和中国中医科学院张伯礼院士团队已经开展了一项多中心随机化系统在“芪参益气滴丸对心肌梗死二级预防的临床试验研究”项目中的应用“研究，当时获得了国家科技进步二等奖。本次启动这项多中心研究，旨在通过循证医学大样本的研究来证明芪参益气滴丸在治疗心衰方面能够给患者带来更多的获益，改善患者的生存质量和生存时间。对于这项研究天士力是有信心的，同时对于芪参益气滴丸的市场前景也是非常看好的。

注：苏晶，天士力医药营销集团市场部总经理。

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2015-11-17 meichuangyi

#天士力#

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2016-07-12 redcrab

#多中心研究#

36 0
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2015-12-25 flyingeagle87

#专访#

31 0
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2016-04-03 luoxiaog

#多中心#

44 0
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2015-10-26 1ddd0b24m59(暂无匿称)

好药

144 0
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2015-10-25 fengzhigu

饭

141 0
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2015-10-25 fatalmelanie

中药需要国家投入去研究，肯定有大收获

150 0
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2015-10-25 fatalmelanie

加油

182 0
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2015-10-24 sanshengshi

赞

95 0
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2015-10-24 yuanming7

#心衰患者#

25 0

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MedSci 专访天士力苏晶：芪参益气滴丸治疗中国心衰患者多中心研究启动