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Int Arch Allergy Immunol:过敏性鼻炎中牛磺酸的体内外抗过敏作用

2020-06-06 AlexYang MedSci原创

目前过敏性鼻炎(AR)的治疗并不完善。最近,有研究人员调查了牛磺酸对AR的治疗作用,并鉴定了潜在的机制。

目前过敏性鼻炎(AR)的治疗并不完善。最近,有研究人员调查了牛磺酸对AR的治疗作用,并鉴定了潜在的机制。

临床上,研究人员发现AR患者中血清中SOD3水平减少。牛磺酸治疗在HMC-1细胞中能够导致SOD3的蛋白和mRNA以剂量依赖的方式增加。SOD3的产生受过氧化物酶体增殖物激活受体-γ(PPAR-γ)调控,并对牛磺酸有响应。SOD3的过表达能够抑制促炎性细胞活素的释放,包括了肿瘤凋亡因子-α、白介素(IL)-4和IL-6。同时,还能够改善干扰素-γ的损失。SOD3和PPAR-γ能够通过调控细胞外信号调节激酶1/2(ERK1/2)的磷酸化影响炎症细胞因素的产生。OVA诱导的AR动物模型表明了牛磺酸在减轻过敏性炎症反应方面是有效的,能够减少AR小鼠的过敏性症状行为和减少嗜酸性细胞和肥大细胞浸润鼻腔。另外,牛磺酸治疗还能够增加SOD3和PPAR-γ的产生,从而通过磷酸化ERK1/2抑制促炎性细胞因子的表达。

最后,研究人员指出,牛磺酸能够作为过敏性障碍治疗的一种可能药物。

原始出处:

Jing Zhou , Yi Lu , Fengqian Li et al. In Vitro and in Vivo Antiallergic Effects of Taurine on Allergic Rhinitis. Int Arch Allergy Immunol. 15 May 2020.

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    2020-06-08 膀胱癌
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    2020-06-08 gj0734

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