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Eur Heart J:Takotsubo综合征患者冠状动脉疾病的有无和结局

2020-06-11 MedSci原创 MedSci原创

TTS患者常伴有冠状动脉疾病,并表现出包括急性冠状动脉闭塞在内的整个冠状动脉病变,且与不良后果相关。

Takotsubo综合征(TTS)是一种急性心力衰竭综合征,与急性冠状动脉综合征(ACS)具有许多共同特征。尽管最初TTS血管造影冠状动脉正常,但最近的较小型的研究表明TTS患者中可能伴随着冠状动脉疾病(CAD)。

近日,血管领域权威杂志Eur Heart J上发表了一篇研究文章,这项研究旨在确定CAD在大批TTS患者中的共存,特征和预后作用。 研究人员分析了TTS患者的冠状动脉解剖和CAD,纳入标准为符合国际Takotsubo TTS诊断标准,以及在急性期进行心室造影的原始冠状动脉造影。排除标准为视野缺失、质量差的血管造影环和无心室造影的血管造影。

该研究共分析了1016名TTS患者。其中,23.0%的患者有阻塞性CAD,41.2%的患者存在非阻塞性CAD,35.7%的患者具有血管造影正常的冠状动脉。总共有47例患者(4.6%)接受了经皮冠状动脉介入治疗,其中3例患者伴有TTS的急性冠状动脉闭塞和8例伴有TTS的慢性冠状动脉闭塞。CAD与休克、通气和全因死亡发生率增加相关。调整混杂因素后,阻塞性CAD与30天的死亡率相关。与年龄和性别相匹配的ACS人群相比,阻塞性CAD的Takotsubo综合征患者发生休克和死亡的风险与之相当,但通气风险几乎是其两倍。

由此可见,TTS患者常伴有冠状动脉疾病,并表现出包括急性冠状动脉闭塞在内的整个冠状动脉病变,且与不良后果相关。

原始出处:

L Christian Napp.et al.Coexistence and outcome of coronary artery disease in Takotsubo syndrome.Eur Heart J.2020.https://doi.org/10.1093/eurheartj/ehaa210

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    2020-06-12 zhaojie88
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    2020-06-12 slcumt
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    2020-06-12 axin015
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    2020-06-11 神盾医疗局局长Jack

    较小型的研究表明TTS患者中可能伴随着冠状动脉疾病(CAD)。

    0

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