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Immunity:研究发现肺巨噬细胞多种发育途径,或可解释免疫细胞加重肺部疾病的原因

2021-01-05 MedSci原创 MedSci原创

在某些情况下,肺部的免疫细胞会加重病毒侵袭。

在某些情况下,肺部的免疫细胞会加重病毒攻击。

在最近一项新的研究中,瑞典Karolinska研究所的研究人员介绍了巨噬细胞肺部的发育过程,并阐明哪些细胞可能是重度肺部疾病的幕后推手。这项研究有助于今后COVID-19等疾病的治疗,于近期发表在《Immunity》杂志上。

DOI:10.1016/j.immuni.2020.12.003

巨噬细胞是一种免疫细胞,可以保护肺部免受病毒与细菌的侵袭。但在某些情况下,肺巨噬细胞也会导致严重的肺部疾病,如慢性阻塞性肺疾病(COPD)和COVID-19。

在研究中,研究人员利用模型来研究活肺中肺巨噬细胞的发育过程。他们将该模型与RNA测序法相结合进行研究,发现了血液中单核细胞变成肺巨噬细胞的过程。

scRNA-seq实验图释

“在研究中,我们发现典型的单核细胞可以迁移到气道和肺组织,并转化为巨噬细胞以保护肺的健康和功能。同时,我们还发现了一种特殊的单核细胞HLA-DRhi,它是介于血单核细胞和气道巨噬细胞之间的中间免疫细胞。这些HLA-DRhi单核细胞可以离开血液循环,迁移到肺组织中,”领导这项研究的卡罗琳斯卡学院哈丁格医学系副教授timwillinger说。

在移植CD34+细胞后4周,肺中存在血管外CD14+HLA-DRhi单核细胞群

而非典型的单核细胞在肺血管中发育成巨噬细胞后不会迁移到肺组织中。

单核细胞形成巨噬细胞途径

“肺部的某些巨噬细胞可能与一些严重的肺部疾病有关。在呼吸道感染中,肺部的单核细胞会发展成巨噬细胞,从而对抗病毒和细菌。但某种类型的巨噬细胞也可能导致严重的炎症和感染,”该研究的第一作者、Tim Willinger研究团队的博士生Elza Evren说。

研究人员认为在新型冠状病毒SARS-COV-2的感染中,保护性、抗炎性的巨噬细胞会被血单核细胞转化成的促炎性肺巨噬细胞所取代。

“已有研究证明这些来自血单核细胞的巨噬细胞与人体在COVID-19中的病情严重程度及肺部的损害程度有关。严重的COVID-19患者血液中的HLA-DRhi单核细胞较少,可能是因为它们离开了血液进入肺部。我们的研究结果表明,未来的治疗应聚焦于炎症巨噬细胞和单核细胞,以减少严重COVID-19造成的肺损伤,降低死亡率。” Tim Willinger说。

原始出处:Elza Evren, Emma Ringqvist, Kumar Parijat Tripathi, et al.  Distinct developmental pathways from blood monocytes generate human lung macrophage diversity. Immunity. 30 December 2020

参考资料:https://medicalxpress.com/news/2021-01-severe-virus-lungs.html

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    2022-04-08 邝医生

    好文

    0

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    2021-11-19 ms8000000532965924

    每日学习安排上

    0

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    2021-09-27 heli0118
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    2021-01-06 neurowu
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    2021-01-05 jyzxjiangqin

    好文章!

    0

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    2021-01-05 mskeeplearning2021

    学习了

    0

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    2021-01-05 weigq

    长知识!

    0

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