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Int J Chron Obstruct Pulmon Dis:需要住院治疗的AECOPD患者QTc延长的意义

2018-08-12 符校魁 罂粟花

QT间期延长与扭转性室速风险增加和心血管死亡有关。COPD急性加重期(AECOPD)具有高心脏病发病率和死亡率的风险,目前尚不清楚QT延长在COPD急性加重期中的发生率和临床相关性。

背景与目的:QT间期延长与扭转性室速风险增加和血管死亡有关。COPD急性加重期(AECOPD)具有高心脏病发病率和死亡率的风险,目前尚不清楚QT延长在COPD急性加重期中的发生率和临床相关性。

方法:方法设计了一种双横断面研究策略。一项回顾性研究评估了140名需要住院的AECOPD患者,其中一半患者入院时心电图QTc延长。进行单因素多变量分析以确定相关因素; Kaplan-Meier和Cox回归分析评估预后意义。 一项前瞻性研究评估了180名需要住院治疗的急性呼吸道疾病患者,以确定入院时延长的QTc是否代表AECOPD特异性表现,并调查住院期间QTc持续时间的变化。

结果:回顾性分析显示:心电图上的低钾血症,心肌肌钙蛋白T和心电异常及QTc延长显着且独立地相关。 QTc延长与全因死亡率升高有关(HR 2.698(95%CI 1.032-7.055),p = 0.043),然而,校正年龄、FEV1和心肌肌钙蛋白T的这种关联不再显着。前瞻性分析显示:QTc 在被诊断患有AECOPD,肺癌,肺部感染或其他急性肺病的1/3患者中观察到延长,但是在AECOPD中没有更普遍。患有COPD的患者在住院期间后QTc持续时间显着下降。

结论:延长的QTc是AECOPD期间潜在血管疾病的标志物。它不是COPD特异表现,而是在肺病急性期需要紧急住院时才常被发现。

原始出处

Van Oekelen O, Vermeersch K, Everaerts S, et al. Significance of prolonged QTc in acute exacerbations of COPD requiring hospitalization. Int J Chron Obstruct Pulmon Dis. Jun 14,2018 ;13:1937-1947. doi: 10.2147/COPD.S157630. eCollection 2018.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2012773, encodeId=45492012e7327, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Sep 05 05:13:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795141, encodeId=8f9c1e95141e9, content=<a href='/topic/show?id=1c9f16846fe' target=_blank style='color:#2F92EE;'>#Struc#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16846, encryptionId=1c9f16846fe, topicName=Struc)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a4d285, createdName=日月, createdTime=Fri Dec 28 00:13:00 CST 2018, time=2018-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488836, encodeId=c9bb148883679, content=<a href='/topic/show?id=69675090ca' target=_blank style='color:#2F92EE;'>#COPD患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5090, encryptionId=69675090ca, topicName=COPD患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=852e8475198, createdName=gous, createdTime=Tue Aug 14 10:13:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575032, encodeId=0ad615e503208, content=<a href='/topic/show?id=942c2045b2' target=_blank style='color:#2F92EE;'>#AECOPD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2045, encryptionId=942c2045b2, topicName=AECOPD)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=592616051717, createdName=fengyi817, createdTime=Tue Aug 14 10:13:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=338184, encodeId=8e1333818477, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Aug 12 19:34:08 CST 2018, time=2018-08-12, status=1, ipAttribution=)]
    2018-12-28 日月
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    2018-08-14 gous
  4. [GetPortalCommentsPageByObjectIdResponse(id=2012773, encodeId=45492012e7327, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Sep 05 05:13:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795141, encodeId=8f9c1e95141e9, content=<a href='/topic/show?id=1c9f16846fe' target=_blank style='color:#2F92EE;'>#Struc#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16846, encryptionId=1c9f16846fe, topicName=Struc)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a4d285, createdName=日月, createdTime=Fri Dec 28 00:13:00 CST 2018, time=2018-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488836, encodeId=c9bb148883679, content=<a href='/topic/show?id=69675090ca' target=_blank style='color:#2F92EE;'>#COPD患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5090, encryptionId=69675090ca, topicName=COPD患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=852e8475198, createdName=gous, createdTime=Tue Aug 14 10:13:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575032, encodeId=0ad615e503208, content=<a href='/topic/show?id=942c2045b2' target=_blank style='color:#2F92EE;'>#AECOPD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2045, encryptionId=942c2045b2, topicName=AECOPD)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=592616051717, createdName=fengyi817, createdTime=Tue Aug 14 10:13:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=338184, encodeId=8e1333818477, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Aug 12 19:34:08 CST 2018, time=2018-08-12, status=1, ipAttribution=)]
    2018-08-14 fengyi817
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    2018-08-12 天地飞扬

    了解一下,谢谢分享!

    0

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