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Clin Oncol:患有局部前列腺癌的70岁及以上并且经历根治性放射性治疗的患者的综合性老年人评估

2017-06-24 AlexYang MedSci原创

70岁及以上且患有局部前列腺癌的男性的治疗选择是需要考虑很多因素的,比如来自竞争原因的死亡风险和拟治疗的适合度。客观的评估,比如那些包括在综合性老年人评估(CGA)中的内容也许可以帮助治疗方案的决定过程。最近,有研究人员进行了旨在描述一个患有前列腺癌男性老人群体的CGA得分,并且评估了潜在的筛选工具以及评估是否CGA内容可以预测重大急性放射毒性。该研究是个预期性的群体研究,并进行了CGA的预处理,

70岁及以上且患有局部前列腺癌的男性的治疗选择是需要考虑很多因素的,比如来自竞争原因的死亡风险和拟治疗的适合度。客观的评估,比如那些包括在综合性老年人评估(CGA)中的内容也许可以帮助治疗方案的决定过程。最近,有研究人员进行了旨在描述一个患有前列腺癌男性老人群体的CGA得分,并且评估了潜在的筛选工具以及评估是否CGA内容可以预测重大急性放射毒性。

该研究是个预期性的群体研究,并进行了CGA的预处理,VES量表(VES-13)和在70岁及以上患有局部前列腺癌病并计划进行体外放射治疗病人的G8问卷筛查。在该研究中,总共包括了178名病人,这些病人都经历了CGA,并且进了为期3年的调查。研究发现,55名(30.1%)参与者通过鉴定他们的CGA被定义为有健康需求。VES-13和G8筛选工具表明了与CGA需求具有显著的相关性(分别为P < 0.001 和 X2 = 15.02, P < 0.001),但是他们的敏感性却不令人满意。另外,研究还发现,CGA(或者其组成内容)与显著的急性放射毒性没有关系。最后,研究人员指出,依据CGA,许多患有局部前列腺癌的老年男性是很脆弱的。这些筛选工具不具备足够有效的敏感性来鉴定这个群体。CGA结果也不能预测重大急性放射毒性。

原始出处:

Osborne GEC, Appleyard SA, Gilbert DC et al. Comprehensive Geriatric Assessment in Men Aged 70 Years or Older with Localised Prostate Cancer Undergoing Radical Radiotherapy. Clin Oncol (R Coll Radiol). 4 June 2017.

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    2017-11-22 minlingfeng
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    2017-06-29 虈亣靌

    不错的,学习了,谢谢分享!

    0

  4. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jun 25 18:27:51 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215031, encodeId=ced7215031a6, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sun Jun 25 05:51:27 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214987, encodeId=f77021498e6e, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sun Jun 25 00:31:36 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214983, encodeId=4686214983ba, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4KDsF1g1gUHzGM0LHxX5B5uhEMln8y8iagso9N4XBTQVPmHrCNoT3o8bw80Ds53TpTgcPnKUIfkyw/0, createdBy=bc101976400, createdName=suibian2007bbb, createdTime=Sun Jun 25 00:23:12 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214929, encodeId=5e6e214929ce, content=依据CGA,许多患有局部前列腺癌的老年男性是很脆弱的, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Jun 24 22:36:54 CST 2017, time=2017-06-24, status=1, ipAttribution=)]
    2017-06-26 chg122
  5. 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objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sun Jun 25 00:31:36 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214983, encodeId=4686214983ba, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4KDsF1g1gUHzGM0LHxX5B5uhEMln8y8iagso9N4XBTQVPmHrCNoT3o8bw80Ds53TpTgcPnKUIfkyw/0, createdBy=bc101976400, createdName=suibian2007bbb, createdTime=Sun Jun 25 00:23:12 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214929, encodeId=5e6e214929ce, content=依据CGA,许多患有局部前列腺癌的老年男性是很脆弱的, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Jun 24 22:36:54 CST 2017, time=2017-06-24, status=1, ipAttribution=)]
    2017-06-26 jeanqiuqiu
  6. 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channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Jun 24 22:36:54 CST 2017, time=2017-06-24, status=1, ipAttribution=)]
    2017-06-25 虈亣靌

    不错的,学习了,谢谢分享!

    0

  7. 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objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sun Jun 25 00:31:36 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214983, encodeId=4686214983ba, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4KDsF1g1gUHzGM0LHxX5B5uhEMln8y8iagso9N4XBTQVPmHrCNoT3o8bw80Ds53TpTgcPnKUIfkyw/0, createdBy=bc101976400, createdName=suibian2007bbb, createdTime=Sun Jun 25 00:23:12 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214929, encodeId=5e6e214929ce, content=依据CGA,许多患有局部前列腺癌的老年男性是很脆弱的, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Jun 24 22:36:54 CST 2017, time=2017-06-24, status=1, ipAttribution=)]
    2017-06-25 189****1577

    值得推荐一下

    0

  8. 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objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sun Jun 25 00:31:36 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214983, encodeId=4686214983ba, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4KDsF1g1gUHzGM0LHxX5B5uhEMln8y8iagso9N4XBTQVPmHrCNoT3o8bw80Ds53TpTgcPnKUIfkyw/0, createdBy=bc101976400, createdName=suibian2007bbb, createdTime=Sun Jun 25 00:23:12 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214929, encodeId=5e6e214929ce, content=依据CGA,许多患有局部前列腺癌的老年男性是很脆弱的, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Jun 24 22:36:54 CST 2017, time=2017-06-24, status=1, ipAttribution=)]
    2017-06-25 130****4638

    学习了谢谢分享

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1864976, encodeId=0f7118649e680, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed Nov 22 01:32:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046234, encodeId=200d204623474, content=<a href='/topic/show?id=80714e595e5' target=_blank style='color:#2F92EE;'>#局部前列腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47595, encryptionId=80714e595e5, topicName=局部前列腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jun 25 18:27:51 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215031, encodeId=ced7215031a6, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sun Jun 25 05:51:27 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214987, encodeId=f77021498e6e, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sun Jun 25 00:31:36 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214983, encodeId=4686214983ba, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4KDsF1g1gUHzGM0LHxX5B5uhEMln8y8iagso9N4XBTQVPmHrCNoT3o8bw80Ds53TpTgcPnKUIfkyw/0, createdBy=bc101976400, createdName=suibian2007bbb, createdTime=Sun Jun 25 00:23:12 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214929, encodeId=5e6e214929ce, content=依据CGA,许多患有局部前列腺癌的老年男性是很脆弱的, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Jun 24 22:36:54 CST 2017, time=2017-06-24, status=1, ipAttribution=)]
    2017-06-25 suibian2007bbb

    学习

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1864976, encodeId=0f7118649e680, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed Nov 22 01:32:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046234, encodeId=200d204623474, content=<a href='/topic/show?id=80714e595e5' target=_blank style='color:#2F92EE;'>#局部前列腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47595, encryptionId=80714e595e5, topicName=局部前列腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, 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objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sun Jun 25 00:31:36 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214983, encodeId=4686214983ba, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4KDsF1g1gUHzGM0LHxX5B5uhEMln8y8iagso9N4XBTQVPmHrCNoT3o8bw80Ds53TpTgcPnKUIfkyw/0, createdBy=bc101976400, createdName=suibian2007bbb, createdTime=Sun Jun 25 00:23:12 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214929, encodeId=5e6e214929ce, content=依据CGA,许多患有局部前列腺癌的老年男性是很脆弱的, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Jun 24 22:36:54 CST 2017, time=2017-06-24, status=1, ipAttribution=)]
    2017-06-24 有备才能无患

    依据CGA,许多患有局部前列腺癌的老年男性是很脆弱的

    0

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最近,有研究人员评估了刺龙菊木提取物对小鼠中亚硝基甲基脲(NMU)诱导的前列腺癌和DU-145细胞系可能保护作用。研究人员通过提供环丙氯地孕酮、睾酮和亚硝基甲基脲在30只雄性霍尔茨曼小鼠中诱导前列腺癌的形成。研究人员对肿瘤进行了检测,并记录了血液学和生化参数以及嗜多染红细胞微核数目。并通过细胞毒性试验对细胞系进行评估。研究发现,对小鼠进行刺龙菊木提取物口服给药可以显著的降低超氧化物歧化酶丙二醛、N

Cancer Discov:三位一体全新血液检测技术,可为前列腺癌患者提供精准治疗

我们距离前列腺癌的精准医学更近了一步。研究人员已创建了一种三位一体的血液检测,他们声称这种检测技术能够预测前列腺癌或者对PARP抑制剂的反应,还有药物如何影响生存率,以及患者产生耐药性的可能性有多大。

Cell Chem Biol:新一代前列腺癌药物之间的相似之处

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Pre Oncology:科学家找到成功“饿死”癌细胞的天然化合物

德克萨斯大学奥斯汀分校的研究人员发现了一种有潜力的天然化合物,这种化合物可以成功“饿死”前列腺癌癌细胞,使肿瘤缩小。这种化合物存在于姜黄,红葡萄皮和苹果皮中,如果将这三者组合,效果似乎更加强大。完整的研究报告发表于《精密肿瘤学》杂志上。

Brit J Cancer:肿瘤异质性给癌症生物标记研究带来了巨大挑战

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在前列腺癌发展到去势抵抗性(CRPC)阶段的过程中,雄激素受体(AR)发挥着关键作用。雄激素受体抑制剂不能抑制AR或它的剪接异构体AR-V7的表达,因而没有治疗效果。本研究报道,在AR转录起始位点的上游,酪氨酸激酶ACK1(TNK2)在酪氨酸88上磷酸化组蛋白H4。WDR5/MLL2复合物读取H4-Y88磷酸化标记并沉淀转录性活化H3K4-三甲基标记,从而促进AR转录。以ACK1抑制剂(R)-9b

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