BMJ：抗抑郁药使用者同时使用非甾体类抗炎药增加了颅内出血的风险

2015-07-15 MedSci译 MedSci原创

该研究的目的是探讨使用抗抑郁药和非甾体类抗炎药（NSAIDs）治疗的患者颅内出血的风险，并且和那些使用抗抑郁药单并没有服用NSAIDs治疗的风险进行了比较。这项回顾性全国倾向得分匹配的队列研究的数据来自于2009年1月2013年12月1至31日之间韩国全国的医疗保险数据库。参与该研究的患者是第一次（指数日期）接受抗抑郁药治疗，并且在过去一年中

该研究的目的是探讨使用抗抑郁药和非甾体类抗炎药（NSAIDs）治疗的患者颅内出血的风险，并且和那些使用抗抑郁药单并没有服用NSAIDs治疗的风险进行了比较。

这项回顾性全国倾向得分匹配的队列研究的数据来自于2009年1月2013年12月1至31日之间韩国全国的医疗保险数据库。参与该研究的患者是第一次（指数日期）接受抗抑郁药治疗，并且在过去一年中没有处方抗抑郁药的历史。并且在索引日期被排除前一年内被诊断为脑血管疾病的患者。

主要结果是以1:1的比例倾向评分匹配后，用药后30天内因颅内出血而住院的时间。采用匹配的Cox回归模型来比较抗抑郁药治疗时使用和不使用NSAIDs的患者颅内出血的风险。

以1：1的比例倾向评分评估和匹配后，该队列研究的分析共包括4145226人。在整个研究期间，抗抑郁药和NSAIDs的联合使用30天颅内出血的风险高于无NSAIDs的抗抑郁药的使用（危险比1.6，95％置信区间 1.32至1.85）。抗抑郁药物种类之间的颅内出血的风险无统计学意义的差异。

抗抑郁药和NSAIDs的联合使用在开始使用30天内增加了颅内出血的风险。

原始出处：

Ju-Young Shin, director1, Mi-Ju Park, senior researcher1, Shin Haeng Lee, researcher1, So-Hyun Choi, researcher1, Mi-Hee Kim, researcher1, Nam-Kyong Choi, research professor2, Joongyub Lee, research professor2, Byung-Joo Park, professor3,Risk of intracranial haemorrhage in antidepressant users with concurrent use of non-steroidal anti-inflammatory drugs,BMJ,2015.7.14

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#插入话题

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2015-10-19 zhouxue1990

以后用药需谨慎

196 0
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2016-01-02 gaoxiaoe

#BMJ#

108 0
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2016-05-28 wetgdt

#抑郁药#

138 0
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2015-07-16 zhouqu_8

#非甾体类抗炎药#

137 0
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2015-07-16 xinmeili

#抗炎药#

113 0
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2015-07-16 wushaoling

#抗抑郁#

107 0

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BMJ：抗抑郁药使用者同时使用非甾体类抗炎药增加了颅内出血的风险

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