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AP&T: IPAA术后存在无症状储袋的患者行内窥镜检查会增加储袋炎的风险

2019-10-05 不详 MedSci原创

本项研究旨在调查了解无症状储袋患者行内窥镜检查是否与随后的储袋炎发展存在关系。

背景

本项研究旨在调查了解无症状储袋患者行内窥镜检查是否与随后的储袋炎发展存在关系。


方法

研究人员回顾性分析了诊断有UC的患者,这些患者接受了回肠肛门吻合术(IPAA)的全结肠直肠癌切除术。储袋炎疾病活动指数(PDAI)症状亚评分为零的无症状患者接受了内窥镜检查。内窥镜检查储袋炎症的被分级为0:正常,1:粘膜炎症或2:粘膜破裂(溃疡和/或糜烂)。主要观察结局为原发性急性特发性储袋炎,定义为PDAI评分≥7,症状持续时间少于4周且对标准抗生素有反应,否则不符合继发性储袋炎的标准。次要观察结果是慢性特发性储袋炎,定义为PDAI评分≥7,尽管使用标准抗生素,但症状持续超过4周。


结果

本项研究共包括143例无症状储袋袋患者。内窥镜检查储袋炎症活度为0的有86例(60.1%)、26例(18.2%)为1,31例(21.7%)为2。原发性急性特发性储袋炎发生在44名(31%)患者中,慢性特发性储袋炎发生在12名(8.4%)中。2级内窥镜储袋炎症活动与急性储袋炎的发展有关(HR 2.39,95%CI 1.23-4.67),而与慢性储袋炎无关(HR 1.76,95%CI 0.53-5.87)。


结论

无症状储袋患者行内窥镜检查会导致近四分之一的无症状IPAA患者中出现粘膜破裂,并与急性储袋炎风险增加相关。


原始出处:

Maia Kayal. Et al. Endoscopic activity in asymptomatic patients with an ileal pouch is associated with an increased risk of pouchitis. Alimentary Pharmacology & Therapeutics. 2019.


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    2020-06-01 qindq
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