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AACR 2015:乳房组织密度的人种差异

2015-04-21 Mechront 译 MedSci原创

声明:本文探讨的不是胸与手感,而是会增加骇人听闻臭名昭著的乳腺癌风险的高密度乳房组织。 就目前的研究看来,除了年龄、BMI、激素治疗、生育史、家族史、BRCA1、BRCA2基因缺陷等因素,高密度乳房组织也会显著增加乳腺癌风险。乳房组织密度是指乳房X线照片时观察到的乳腺纤维腺体组织密度,因为乳腺纤维腺体组织在X片上显示为白色,以至于乳腺癌很难直观的检测到。研究显示,高密度乳房组织女性比低密度女

声明:本文探讨的不是胸与手感,而是会增加骇人听闻臭名昭著的乳腺癌风险的高密度乳房组织。

就目前的研究看来,除了年龄、BMI、激素治疗、生育史、家族史、BRCA1、BRCA2基因缺陷等因素,高密度乳房组织也会显著增加乳腺癌风险。乳房组织密度是指乳房X线照片时观察到的乳腺纤维腺体组织密度,因为乳腺纤维腺体组织在X片上显示为白色,以至于乳腺癌很难直观的检测到。研究显示,高密度乳房组织女性比低密度女性,有高达4-6倍的乳腺癌风险。

McCarthy等人对2010-2011年间,于宾夕法尼亚大学行乳腺X片筛查的1589名黑人女性和1256名白人女性,使用了新的、定量的、可能更可靠的测量乳房组织密度的方法。

通常当病人行乳房X线检查时,放射科医生会对其评估乳房组织密度,但是该结果并不是客观的,具体主观人为因素。相反,该研究中McCarthy等人通过完全自动化的计算机算法,检测二维的乳房组织密度和三维的乳房体积估计密度。

该研究发现,黑人女性的乳房绝对面积密度为40.1 cm2,远远超过白人女性的33.1 cm2。不仅如此,在乳房体积密度方面,黑人女性也明显高于白人:187.2 cm3 vs. 181.6 cm3。校正影响乳腺癌风险的其他因素后发现,黑人女性的乳房组织密度仍远高于白人女性。

研究表明,通过这种新的定量检测方法发现黑人女人比白人女性有着更高的乳房组织密度。

原始出处:

AACR Annual Meeting 2015:Black Women Found to Have Denser Breast Tissue Than White Women.

本文系Medsci原创编译整理!转载需要先获得授权,并附原文链接。谢谢!

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    2021-11-20 湘雅科教

    已阅,受益匪浅。

    0

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    2017-06-15 1decafd9m46(暂无匿称)

    乳腺比脂肪多的风险更高,也就是乳房坚挺质韧的

    0

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    2015-07-05 Gsurgeon

    什么意思

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1072115, encodeId=40be10e2115ae, content=已阅,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Sat Nov 20 10:30:17 CST 2021, time=2021-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211105, encodeId=301a211105c5, content=乳腺比脂肪多的风险更高,也就是乳房坚挺质韧的, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRtNT7AWKboIfjpeY6Nw6lNxAc4w1aibutHSqCJ2c3AbwfqpRia4IrnzU2mK3Ojx2Har8AUUyhC0kl7/0, createdBy=ecc31722157, createdName=1decafd9m46(暂无匿称), createdTime=Thu Jun 15 12:57:18 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804850, encodeId=4b5a18048508a, content=<a href='/topic/show?id=8f66e768963' target=_blank style='color:#2F92EE;'>#组织密度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77689, encryptionId=8f66e768963, topicName=组织密度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5bc315, createdName=Tommy1949, createdTime=Thu Feb 18 14:19:00 CST 2016, time=2016-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30741, encodeId=174230e4152, content=什么意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Sun Jul 05 06:08:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400318, encodeId=31681400318dc, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Thu Apr 23 10:19:00 CST 2015, time=2015-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551958, encodeId=0ecc155195853, content=<a href='/topic/show?id=169c166430' target=_blank style='color:#2F92EE;'>#AACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1664, encryptionId=169c166430, topicName=AACR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6b2714248200, createdName=Luyuxie_14, createdTime=Thu Apr 23 10:19:00 CST 2015, time=2015-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=21651, encodeId=7c51216517a, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=cspcsp, createdTime=Wed Apr 22 00:33:00 CST 2015, time=2015-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=21652, encodeId=ba2b216526f, content=不可思议, beContent=null, objectType=article, channel=null, level=null, likeNumber=212, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=cspcsp, createdTime=Wed Apr 22 00:33:00 CST 2015, time=2015-04-22, status=1, ipAttribution=)]
    2015-04-23 10518094zz
  6. [GetPortalCommentsPageByObjectIdResponse(id=1072115, encodeId=40be10e2115ae, content=已阅,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Sat Nov 20 10:30:17 CST 2021, time=2021-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211105, encodeId=301a211105c5, content=乳腺比脂肪多的风险更高,也就是乳房坚挺质韧的, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRtNT7AWKboIfjpeY6Nw6lNxAc4w1aibutHSqCJ2c3AbwfqpRia4IrnzU2mK3Ojx2Har8AUUyhC0kl7/0, createdBy=ecc31722157, createdName=1decafd9m46(暂无匿称), createdTime=Thu Jun 15 12:57:18 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804850, encodeId=4b5a18048508a, content=<a href='/topic/show?id=8f66e768963' target=_blank style='color:#2F92EE;'>#组织密度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77689, encryptionId=8f66e768963, topicName=组织密度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5bc315, createdName=Tommy1949, createdTime=Thu Feb 18 14:19:00 CST 2016, time=2016-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30741, encodeId=174230e4152, content=什么意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Sun Jul 05 06:08:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400318, encodeId=31681400318dc, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Thu Apr 23 10:19:00 CST 2015, time=2015-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551958, encodeId=0ecc155195853, content=<a href='/topic/show?id=169c166430' target=_blank style='color:#2F92EE;'>#AACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1664, encryptionId=169c166430, topicName=AACR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6b2714248200, createdName=Luyuxie_14, createdTime=Thu Apr 23 10:19:00 CST 2015, time=2015-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=21651, encodeId=7c51216517a, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=cspcsp, createdTime=Wed Apr 22 00:33:00 CST 2015, time=2015-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=21652, encodeId=ba2b216526f, content=不可思议, beContent=null, objectType=article, channel=null, level=null, likeNumber=212, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=cspcsp, createdTime=Wed Apr 22 00:33:00 CST 2015, time=2015-04-22, status=1, ipAttribution=)]
    2015-04-23 Luyuxie_14
  7. [GetPortalCommentsPageByObjectIdResponse(id=1072115, encodeId=40be10e2115ae, content=已阅,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Sat Nov 20 10:30:17 CST 2021, time=2021-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211105, encodeId=301a211105c5, content=乳腺比脂肪多的风险更高,也就是乳房坚挺质韧的, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRtNT7AWKboIfjpeY6Nw6lNxAc4w1aibutHSqCJ2c3AbwfqpRia4IrnzU2mK3Ojx2Har8AUUyhC0kl7/0, createdBy=ecc31722157, createdName=1decafd9m46(暂无匿称), createdTime=Thu Jun 15 12:57:18 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804850, encodeId=4b5a18048508a, content=<a href='/topic/show?id=8f66e768963' target=_blank style='color:#2F92EE;'>#组织密度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77689, encryptionId=8f66e768963, topicName=组织密度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5bc315, createdName=Tommy1949, createdTime=Thu Feb 18 14:19:00 CST 2016, time=2016-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30741, encodeId=174230e4152, content=什么意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Sun Jul 05 06:08:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400318, encodeId=31681400318dc, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Thu Apr 23 10:19:00 CST 2015, time=2015-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551958, encodeId=0ecc155195853, content=<a href='/topic/show?id=169c166430' target=_blank style='color:#2F92EE;'>#AACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1664, encryptionId=169c166430, topicName=AACR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6b2714248200, createdName=Luyuxie_14, createdTime=Thu Apr 23 10:19:00 CST 2015, time=2015-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=21651, encodeId=7c51216517a, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=cspcsp, createdTime=Wed Apr 22 00:33:00 CST 2015, time=2015-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=21652, encodeId=ba2b216526f, content=不可思议, beContent=null, objectType=article, channel=null, level=null, likeNumber=212, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=cspcsp, createdTime=Wed Apr 22 00:33:00 CST 2015, time=2015-04-22, status=1, ipAttribution=)]
    2015-04-22 cspcsp

    有用

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1072115, encodeId=40be10e2115ae, content=已阅,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Sat Nov 20 10:30:17 CST 2021, time=2021-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211105, encodeId=301a211105c5, content=乳腺比脂肪多的风险更高,也就是乳房坚挺质韧的, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRtNT7AWKboIfjpeY6Nw6lNxAc4w1aibutHSqCJ2c3AbwfqpRia4IrnzU2mK3Ojx2Har8AUUyhC0kl7/0, createdBy=ecc31722157, createdName=1decafd9m46(暂无匿称), createdTime=Thu Jun 15 12:57:18 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804850, encodeId=4b5a18048508a, content=<a href='/topic/show?id=8f66e768963' target=_blank style='color:#2F92EE;'>#组织密度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77689, encryptionId=8f66e768963, topicName=组织密度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5bc315, createdName=Tommy1949, createdTime=Thu Feb 18 14:19:00 CST 2016, time=2016-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30741, encodeId=174230e4152, content=什么意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Sun Jul 05 06:08:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400318, encodeId=31681400318dc, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Thu Apr 23 10:19:00 CST 2015, time=2015-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551958, encodeId=0ecc155195853, content=<a href='/topic/show?id=169c166430' target=_blank style='color:#2F92EE;'>#AACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1664, encryptionId=169c166430, topicName=AACR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6b2714248200, createdName=Luyuxie_14, createdTime=Thu Apr 23 10:19:00 CST 2015, time=2015-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=21651, encodeId=7c51216517a, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=cspcsp, createdTime=Wed Apr 22 00:33:00 CST 2015, time=2015-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=21652, encodeId=ba2b216526f, content=不可思议, beContent=null, objectType=article, channel=null, level=null, likeNumber=212, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=cspcsp, createdTime=Wed Apr 22 00:33:00 CST 2015, time=2015-04-22, status=1, ipAttribution=)]
    2015-04-22 cspcsp

    不可思议

    0

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