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J Endod:欧米伽-3脂肪酸可以减少大鼠根尖周炎的炎症反应

2018-02-12 lishiting MedSci原创

这篇研究的目的是为了评估欧米伽-3多不饱和脂肪酸(ω-3 PUFAs)对牙髓暴露诱导的根尖周炎(AP)大鼠模型促炎症及抗炎症因子的影响。

这篇研究的目的是为了评估欧米伽-3多不饱和脂肪酸(ω-3 PUFAs)对牙髓暴露诱导的根尖周炎(AP)大鼠模型促炎症及抗炎症因子的影响。

研究将28只雄性Wistar大鼠分为4组:对照组,未施加任何治疗(组C);施以ω-3 PUFAs的对照组(组C-O);牙髓暴露诱导的AP组(组AP);牙髓暴露诱导的AP施以ω-3 PUFAs组(组AP-O)。牙髓暴露前,ω-3 PUFAs每日口服给药15天,并且这种治疗在牙髓暴露后再施以30天。牙髓暴露30天后处死实验大鼠,并分离颌骨进行免疫组化分析来检测尖周骨表面的肿瘤坏死因子α (TNF-α), 白细胞介素(IL)-6, IL-1β, IL-17和IL-10的免疫反应。结果通过方差分析及Tukey post检验进行统计学评估。显著性水平设置为5%。

结果显示,AP组的促炎症因子TNF-α, IL-6, IL-1β和IL-17的免疫反应要高于AP-O, C和C-O组(P < .05)。而AP组的抗炎症因子IL-10的免疫反应却明显低于AP-O组(P < .05)。

结论:ω-3 PUFAs的补充给药法可以调节AP大鼠的炎症反应,减少TNF-α, IL-6, IL-1β和IL-17的表达水平,却会增加IL-10的表达水平。

原始出处

Azuma MM, Gomes-Filho JE, et al. Omega-3 Fatty Acids Reduce Inflammation in Rat Apical Periodontitis. J Endod. 2018 Jan 31. pii: S0099-2399(17)31299-2. doi: 10.1016/j.joen.2017.12.008.

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    2018-02-12 lou.minghong

    学习了.谢谢分享!

    0

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